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Results for "

brucei

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) AMPK (1) Antibiotic (4) Apolipoprotein (1) Apoptosis (5) Aurora Kinase (1) Autophagy (4) Bacterial (10) Biochemical Assay Reagents (1) Cathepsin (3) CDK (1) Cholinesterase (ChE) (2) Clathrin (1) COX (2) Cytochrome P450 (3) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (4) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (4) Environmental Pollutants (1) Farnesyl Transferase (1) Fluorescent Dye (1) Fungal (3) Glycosidase (2) GSK-3 (2) IFNAR (1) IMPDH (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Mitochondrial Metabolism (3) Mitosis (1) PAK (1) Paraptosis (3) Parasite (97) Phosphodiesterase (PDE) (3) Phospholipase (2) PKA (1) Proteasome (2) Reference Standards (7) Ser/Thr Protease (1) STAT (3) TNF Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (107) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Adenosine Kinase (1)

AMPK (1)

Antibiotic (4)

Apolipoprotein (1)

Apoptosis (5)

Aurora Kinase (1)

Autophagy (4)

Bacterial (10)

Biochemical Assay Reagents (1)

Cathepsin (3)

CDK (1)

Cholinesterase (ChE) (2)

Clathrin (1)

COX (2)

Cytochrome P450 (3)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (4)

Drug Derivative (2)

Drug Intermediate (1)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (4)

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Farnesyl Transferase (1)

Fluorescent Dye (1)

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IFNAR (1)

IMPDH (1)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1)

Mitochondrial Metabolism (3)

Mitosis (1)

PAK (1)

Paraptosis (3)

Parasite (97)

Phosphodiesterase (PDE) (3)

Phospholipase (2)

PKA (1)

Proteasome (2)

Reference Standards (7)

Ser/Thr Protease (1)

STAT (3)

TNF Receptor (1)

Topoisomerase (1)

By Research Areas:

Cancer (16)

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Infection (107)

Inflammation/Immunology (10)

Metabolic Disease (3)

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121

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125731

Glycodeoxycholic acid 3 Publications Verification	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-12054

Hesperadin Maximum Cited Publications 12 Publications Verification	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .

HY-103056

DDD85646 1 Publications Verification IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .

HY-13801

Fexinidazole 4 Publications Verification HOE 239	Parasite	Infection
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC₅₀s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei .

HY-128170

Ebsulfur	Parasite	Infection
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC₅₀ values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .

HY-19910

Acoziborole 3 Publications Verification SCYX-7158; AN5568	Parasite	Infection
Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .

HY-N0389

Columbin 1 Publications Verification	COX Parasite	Inflammation/Immunology
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-N2230

N-p-trans-Coumaroyltyramine	Cholinesterase (ChE) Parasite Glycosidase	Infection Neurological Disease
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC₅₀: 122 μM) and α-glucosidase (IC₅₀: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC₅₀ of 13.3 µM against T. brucei* rhodesiense*. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease .

HY-153021

NMT-IN-1	Parasite	Infection
NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC₅₀ of 31 μM against TbNMT and an IC₅₀ of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .

HY-N7266

Obtusifoliol 1 Publications Verification	Cytochrome P450 Parasite	Infection Cancer
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM .

HY-12607

ML251	Parasite	Infection
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC₅₀=0.37 μM) and T. cruzi PFK (IC₅₀=0.13 μM). ML251 can be used for the research of parasite .

HY-128268

PFK-IN-1	Parasite	Infection
PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC₅₀ values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED₅₀ of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-125731R

Glycodeoxycholic Acid (Standard)	Reference Standards Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-W052512

Antitrypanosomal agent 1	Parasite	Infection
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC₅₀ of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC₅₀=64.8 μM) and T. brucei (EC₅₀=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity .

HY-111759

Jaspamycin 1 Publications Verification 7-CN-7-C-Ino	PKA Parasite	Infection
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-135562

Ascofuranone	Parasite Antibiotic	Infection Cancer
Ascofuranone is an orally active inhibitor of *Trypanosoma brucei* brucei (TAO) with a K_i** value of 2.38 nM. Ascofuranone inhibits IGF-1-induced cancer cell migration, invasion, motility and actin cytoskeleton formation, and exerts anti-tumor effects. Ascofuranone can be used in research related to tumor metastasis, African trypanosomiasis, bacterial infections, lung cancer and hepatocellular carcinoma .

HY-155655

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-W043676

Dibenzosuberol	Parasite Drug Intermediate	Infection
Dibenzosuberol (Compound 2) is a key intermediate in the synthesis of compounds associated with inhibiting Trypanosoma thiol reductase (TryR). Dibenzosuberol also shows inhibition of T. brucei with an EC₅₀ value of 51.3 μM. Dibenzosuberol is also an impurity of Amitriptyline (HY-B0527) .

HY-169932

APOL1-IN-2	Apolipoprotein	Infection
APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 (APOL1). APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC₅₀ of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC₅₀ of 2.24, 6.03 and 3.72 nM, respectively .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-W973644

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections .

HY-179690

Antiparasitic agent-30	Parasite Adenosine Kinase	Infection
Antiparasitic agent-30 is a potent adenosine kinase TbrAK modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei* rhodesiense, while enhancing the activity of recombinant TbrAK(EC₅₀=38 nM, K_a=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense*. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) .

HY-155531

PEX5-PEX14 PPI-IN-2	Biochemical Assay Reagents	Infection
PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC₅₀ values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection .

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-Q40175

Antitrypanosomal agent 9	Parasite	Infection
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC₅₀ of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .

HY-W009689

TbPTR1 inhibitor 2	Parasite	Infection
TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC₅₀s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC₅₀: 34.2 μM) .

HY-16121

CAA-0225	Cathepsin	Others
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC₅₀ value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites ^[1][2][3].

HY-155530

PEX5-PEX14 PPI-IN-1	Bacterial	Infection
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a K_i of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC₅₀: 5 μM) .

HY-118996A

Isometamidium chloride	Parasite	Infection
Isometamidium chloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride can be used in research of african sleeping sickness .

HY-101015

(2E)-OBAA	Phospholipase Apoptosis	Inflammation/Immunology
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM .

HY-N0389R

Columbin (Standard)	Reference Standards COX Parasite	Inflammation/Immunology
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-136200

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .

HY-116045

PDEB1-IN-1	Parasite	Cancer
PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC₅₀ of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC₅₀ of 26 μM .

HY-161237

Antitrypanosomal agent 20	Parasite	Infection
Antitrypanosomal agent 20 (Compd 27) is an anti-trypanosomal, with an IC₅₀ of 0.75 μM for T. b. brucei .

HY-147933

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC₅₀ value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) .

HY-147940

TbPTR1 inhibitor 1	Parasite	Infection
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC₅₀<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC₅₀=0.66 μM) .

HY-N16437

Panowamycin A	Parasite	Infection
Panowamycin A is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin A exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 0.40 μg/mL). Panowamycin A shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 2.95 μg/mL). Panowamycin A can be used for research in the field of antitrypanosomal studies .

HY-170363

Proteasome-IN-6	Proteasome Parasite	Infection
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC₅₀s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model .

HY-147549

Antitrypanosomal agent 6	Parasite	Infection
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-147550

Antitrypanosomal agent 7	Parasite	Infection
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC₅₀ value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .

HY-175517

PEX5-PEX14 PPI-IN-3	Parasite	Infection
PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC₅₀ of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC₅₀ of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity .

HY-168538

Antitrypanosomal agent 21	Paraptosis	Infection
Antitrypanosomal agent 21 (Compound C-1) is a trypanosoma brucei inhibitor. Antitrypanosomal agent 21 decreases the level of D6XM23 in parasite lysates .

HY-146071

Antitrypanosomal agent 5	Parasite	Infection
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively .

HY-155024

HAT-IN-8	Parasite	Infection
HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HY-111906

SCYX-6759	Cytochrome P450 Parasite	Infection
SCYX-6759 is an orally active, blood-brain barrier permeable anti-T. brucei agent. SCYX-6759 inhibits cytochrome P450 (IC₅₀s: 30.3, 30.6, 47.4 μM for 2D6, 2C9, 2C19, respectively.) SCYX-6759 exhibits potent activity against T. b. brucei 427, T. b. rhodesiense STIB900, and T. b. gambiense STIB930, with IC₅₀s of 0.07, 0.038 and 0.030 μg/mL, respectively .

HY-149986

Antitrypanosomal agent 13	Parasite	Infection
Antitrypanosomal agent 13 (compound 4b) is a potent antitrypanosomal agent. Antitrypanosomal agent 13 has trypanocidal and cytotoxic activity with GI₅₀ values of 0.18 and 8.4 μM for T. brucei and HL-60, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125731

Glycodeoxycholic acid 3 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-135190

(-)-Cedrene 2 Publications Verification α-cedrene	Infection Structural Classification Cedrus deodara (Roxburgh) G. Don Classification of Application Fields Pinaceae Terpenoids Sesquiterpenes Metabolic Disease Plants Disease Research Fields Source Classification	Environmental Pollutants Bacterial
(-)-Cedrene (α-cedrene) is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC₅₀ = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC₅₀ = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .

HY-N0389

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-N2230

N-p-trans-Coumaroyltyramine	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Source Classification	Cholinesterase (ChE) Parasite Glycosidase
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC₅₀: 122 μM) and α-glucosidase (IC₅₀: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC₅₀ of 13.3 µM against T. brucei* rhodesiense*. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease .

HY-N7266

Obtusifoliol 1 Publications Verification	Infection Natural Products Human Gut Microbiota Metabolites Sorghum bicolor (Linn.) Moench Microorganisms Classification of Application Fields Gramineae Plants Endogenous metabolite Disease Research Fields Source Classification	Cytochrome P450 Parasite
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-125731R

Glycodeoxycholic Acid (Standard)	Structural Classification Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-111759

Jaspamycin 1 Publications Verification 7-CN-7-C-Ino	Marine natural products Source Classification	PKA Parasite
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .

HY-N11173A

trans-Melilotoside	Structural Classification Leguminosae Dendranthema morifolium (Ramat.) Tzvel. Coumarins Phenylpropanoids Plants Source Classification	Parasite
trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria ^[1] ^[3].

HY-N7634

Tectol	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-N16437

Panowamycin A	Natural Products Microorganisms Source Classification	Parasite
Panowamycin A is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin A exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 0.40 μg/mL). Panowamycin A shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 2.95 μg/mL). Panowamycin A can be used for research in the field of antitrypanosomal studies .

HY-N11550

Salviandulin E	Artemisia frigida Willd. Terpenoids Labiatae Diterpenoids Plants Source Classification	Parasite
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against *T. b. brucei* GUTat 3.1 parasites with an IC₅₀** value of 0.72 µg/mL .

HY-N3247

Monomethyl kolavate	Terpenoids Labiatae Diterpenoids Plants Inula grandis Schrenk ex Fish.. Source Classification	Parasite
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-N1985

Acetylastragaloside I	Triterpenes Structural Classification Tetracyclic Triterpenoids Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for **T. brucei* rhodesiense* and T. cruzi**, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

HY-N8476

Sahandol	Chrysanthemum × morifolium (Ramat.) Hemsl. Terpenoids Labiatae Diterpenoids Plants Source Classification	Parasite
Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities .

HY-N2230R

N-p-trans-Coumaroyltyramine (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards Cholinesterase (ChE) Parasite Glycosidase
N-p-trans-Coumaroyltyramine (Standard) is the analytical standard of N-p-trans-Coumaroyltyramine (HY-N2230). This product is intended for research and analytical applications. N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC₅₀: 122 μM) and α-glucosidase (IC₅₀: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC₅₀ of 13.3 µM against T. brucei* rhodesiense*. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease.

HY-135190R

(-)-Cedrene (Standard) α-cedrene (Standard)	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Plants Source Classification	Bacterial Reference Standards
(-)-Cedrene (α-cedrene) (Standard) is the analytical standard of (-)-Cedrene. This product is intended for research and analytical applications. (-)-Cedrene is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC₅₀ = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC₅₀ = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .

HY-N16437A

Panowamycin B	Natural Products Microorganisms Source Classification	Parasite
Panowamycin B is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin B exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 3.30 μg/mL). Panowamycin B shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 13 μg/mL). Panowamycin B can be used for research in the field of antitrypanosomal studies .

HY-N19754

Cladospirone B	Structural Classification Natural Products Microorganisms Source Classification	Parasite
Cladospirone B is a secondary metabolite of the endophytic fungus Lasiodiplodia theobromae. Cladospirone B exhibits trypanocidal activity, with a MIC of 17.8 µM against Trypanosoma brucei. Cladospirone B can be used in the research of African human trypanosomiasis (sleeping sickness) .

HY-N19727

Chamissonolide	Arnica chamissonis Less. Structural Classification Terpenoids Sesquiterpenes Plants Compositae Source Classification	Interleukin Related IFNAR TNF Receptor Apoptosis
Chamissonolide is a sesquiterpene lactone with cytotoxic, anti-inflammatory and trypanocidal activities. Chamissonolide reduces the mRNA levels of IL-2, IFN-γ, GM-CSF, iNOS and TNF-α, and upregulates the mRNA level of NF-ATc. Chamissonolide decreases the population of naturally occurring apoptotic cells. Chamissonolide can be used in research related to tumors, African trypanosomiasis and Chagas disease .

HY-W701798

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Structural Classification Alkaloids Cuscuta reflexa Roxb. Plants Isoquinoline Alkaloids Convolvulaceae Cuscuta chinensis Lam. Source Classification	Drug Derivative
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

Cat. No.	Product Name	Chemical Structure

HY-W653999

Glycodeoxycholic acid-d5
Glycodeoxycholic acid-d₅ is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

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