36417-86-4
36417-86-4
Chemical Structure
N-p-trans-Coumaroyltyramine
- CAS No.: 36417-86-4
- Formula:C17H17NO3
- Molecular Weight:283.33
IUPAC Name: (E)-N-(4-hydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide
InChIKey: RXGUTQNKCXHALN-BJMVGYQFSA-N
SMILES: O=C(NCCC1=CC=C(O)C=C1)/C=C/C2=CC=C(O)C=C2
Biological Activity: N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease[1][2][3].
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N-p-trans-Coumaroyltyramine | 99.28% | N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease. | ||||||||||||||||||||
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N-p-trans-Coumaroyltyramine (Standard) | ≥98% | N-p-trans-Coumaroyltyramine (Standard) is the analytical standard of N-p-trans-Coumaroyltyramine (HY-N2230). This product is intended for research and analytical applications. N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC50: 122 μM) and α-glucosidase (IC50: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC50 of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5. [Content Brief]
- [2]. Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8. [Content Brief]
- [3]. Zhou X, et al. Separation and purification of α-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration-HPLC screening. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:149-54. [Content Brief]
