4 Results for "

canine renin

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "canine renin" in MCE Product Catalog:

  • Targets Recommended:
18
Talfirastide
Talfirastide
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18 Cited Publications
Cat. No.: HY-12403
CAS No.: 51833-78-4
Purity:  99.75%
Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE)

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
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18
Talfirastide acetate
Talfirastide acetate
0 Images
18 Cited Publications
Cat. No.: HY-12403A
CAS No.: 2855063-75-9
Purity:  99.87%
Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .
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Talfirastide (Standard)
Talfirastide (Standard)
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Cat. No.: HY-12403R
CAS No.: 51833-78-4
Synonyms: TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards

Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
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H-77
H-77
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Cat. No.: HY-P2647
CAS No.: 82131-82-6
Target:  

Renin Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

H-77 is a selective Renin inhibitor with an IC50 of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system .
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