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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
cofilin
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "cofilin" in MCE Product Catalog:
100
100 Publications Verification
Cat. No.: HY-N6682
CAS No.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Target:
23
Category:
Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Plants Disease Research Fields Isoquinoline Alkaloids Amaryllidaceae Cancer Agricultural Research
Target:
1
1 Cited Publications
Cat. No.: HY-19353
CAS No.: 1219728-20-7
Target:
Research Areas:
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC50 of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases .
Target:
Research Areas:
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .
Cat. No.: HY-170781
CAS No.: 3099003-91-2
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MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research .
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis .
Cat. No.: HY-P5455
Target:
Research Areas:
Cat. No.: HY-16563R
CAS No.: 29477-83-6
Synonyms: Lycoricidinol (Standard)
Category:
Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Plants Isoquinoline Alkaloids Amaryllidaceae
Target:
Cat. No.: HY-174229
Target:
Research Areas:
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion .
Cat. No.: HY-RS02568
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CFL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CFL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-E70841
Target:
Research Areas:
LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions .
Cat. No.: HY-164374
CAS No.: 445007-59-0
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
Cat. No.: HY-P74234
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CFL2; CDNA, FLJ94864, Homo Sapiens cofilin 2 (Muscle) (CFL2), MRNA; cofilin 2; cofilin 2 (Muscle), Isoform CRA_c; NEM7; cofilin 2 (Muscle), Isoform CRA_a; Nemaline Myopathy Type 7; cofilin, Muscle Isoform; cofilin 2 (Muscle); cofilin Isoform; cofilin-2
Cat. No.: HY-P810609
Synonyms: 18 kDa phosphoprotein;
CFL 1;
CFL;
CFL1;
COF1_HUMAN;
cofilin 1;
cofilin 1 non muscle;
cofilin;
cofilin non muscle isoform;
cofilin-1;
epididymis secretory protein Li 15;
HEL-S-15;
non-muscle isoform;
p18
Cat. No.: HY-P81566
Synonyms: 18 kDa phosphoprotein antibody;
CFL 1 antibody;
CFL antibody;
CFL1 antibody;
COF1_HUMAN antibody;
cofilin 1 antibody;
cofilin 1 non muscle antibody;
cofilin antibody;
cofilin non muscle isoform antibody;
cofilin-1 antibody;
epididymis secretory protein Li 15 antibody;
HEL-S-15 antibody;
non-muscle isoform antibody;
p18 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
