SM311
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion.
For research use only. We do not sell to patients.
- Formula: C20H19F2N5O2S
- Molecular Weight:431.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LIMK1 0.045 μM (EC50) |
LIMK2 |
Chemical Information
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Molecular Weight 431.46
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Formula C20H19F2N5O2S
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SMILES
FC(F)C1=NN(C2=CC=C(NC(C=C)=O)C=C2)C(C3=CN=C(NC(C(C)C)=O)S3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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