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Cat. No.: HY-P87883

Cofilin Antibody (YA7568)

Cofilin Antibody (YA7568) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Cofilin.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:20000-1:50000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000

Description

Cofilin Antibody (YA7568) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Cofilin.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 19 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 19 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG,Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes. Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration^[1]^[2]^[3]^[4].
Subcellular Localization

Nucleus matrix,Cytoplasm, cytoskeleton,Cell projection, ruffle membrane,Cell projection, lamellipodium membrane,Cell projection, lamellipodium,Cell projection, growth cone,Cell projection, axon
Expression

Tissue_Specificity: Widely distributed in various tissues
Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)
Isoforms & Post-Translational Modification

P23528: 166 amino acids, molecular weight 18502 Da.
Subunit

Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:11812157)
SwissProt ID

P23528