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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
collagen adhesion
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "collagen adhesion" in MCE Product Catalog:
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4 Cited Publications
Cat. No.: HY-P1408
CAS No.: 404882-00-4
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4 Cited Publications
Cat. No.: HY-P1408A
3
3 Cited Publications
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TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .
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PXS-4728A is an orally active, selective VAP-1/SSAO inhibitor with an IC50 of 5 nM and a Ki of 175 nM. PXS-4728A inhibits the expression of MMP-9. It reduces cell rolling, adhesion and migration, decreases cell infiltration levels, pro-inflammatory cytokines, chemokines and collagen deposition, and improves pulmonary function. PXS-4728A reduces the formation and progression of atherosclerotic plaques, and decreases blood lipid and blood glucose levels as well as body weight gain. PXS-4728A can be used in research related to chronic obstructive pulmonary disease, cystic fibrosis, acute pulmonary inflammation, acute lung injury, bronchiolitis obliterans syndrome, rhinovirus-exacerbated asthma, sepsis, Klebsiella pneumoniae pulmonary infection and atherosclerosis .
1
1 Cited Publications
Cat. No.: HY-E70005H
CAS No.: 9001-12-1
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Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis .
1
1 Cited Publications
Cat. No.: HY-P2975
CAS No.: 114956-81-9
Synonyms: Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)
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Application: cell culture, biological 3D printing, tissue engineering, etc.
Cat. No.: HY-N2163
CAS No.: 172760-03-1
Category:
Other Monoterpenes other families Monophenols Terpenoids Other Diseases Phenols Plants Disease Research Fields
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Cat. No.: HY-W129161
CAS No.: 827306-88-7
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Cat. No.: HY-P11328
CAS No.: 245120-10-9
Cat. No.: HY-NP132A
Cat. No.: HY-NP132
Cat. No.: HY-N2600
CAS No.: 76472-87-2
Cat. No.: HY-P5832
CAS No.: 836606-84-9
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Cat. No.: HY-P11087
CAS No.: 134335-45-8
Research Areas:
Cat. No.: HY-158225
Synonyms: Col1MA
Application: cell culture, biological 3D printing, tissue engineering, etc.
Cat. No.: HY-NP162
Cat. No.: HY-177331
CAS No.: 1259029-47-4
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Research Areas:
BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .
Cat. No.: HY-113612
CAS No.: 682329-63-1
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Cat. No.: HY-168087
CAS No.: 1893340-21-0
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GSK3335103 is an orally active non-peptidic αvβ6 integrin inhibitor with a pIC50 of 8 and a pKi of 9.96. GSK3335103 blocks αvβ6 integrin-mediated cell adhesion and TGF-β1 activation, induces integrin internalization, recycling and lysosomal degradation, attenuates TGFβ signaling and reduces collagen deposition. GSK3335103 decreases the level of pSmad2 in BAL cells and collagen deposition in lung tissues in a mouse model of pulmonary fibrosis. GSK3335103 can be used in research related to pulmonary fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
