682329-63-1
Chemical Structure
Cytostatin
- CAS No.: 682329-63-1
- Formula:C21H33O7P
- Molecular Weight:428.46
IUPAC Name: (2S,5S,6S,7S,8Z,10Z,12E)-7-hydroxy-6-methyl-2-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)tetradeca-8,10,12-trien-5-yl dihydrogen phosphate
InChIKey: PQNNIEWMPIULRS-PZIWEVEYSA-N
SMILES: O=C1C=C[C@H](C)[C@H]([C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)O1
Biological Activity: Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin[1][2][3][4].
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Cytostatin | Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin. | |||||||||||||||||||||
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- [1]. Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128(51):16720-16732. [Content Brief]
- [2]. Kawada M, et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999;1452(2):209-217. [Content Brief]
- [3]. Kawada M, et al. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res. 1999;90(2):219-225. [Content Brief]
- [4]. Bialy L, et al. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chemistry. 2004;10(11):2759-2780. [Content Brief]
Keywords
