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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
copper(I)-catalyzed cycloaddition click reaction
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "copper(I)-catalyzed cycloaddition click reaction" in MCE Product Catalog:
Cat. No.: HY-W615104
CAS No.: 1341215-17-5
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BTTP is a tris(triazolylmethyl)amine-based ligand. BTTP can accelerate the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the prototypical reaction in click chemistry .
Cat. No.: HY-W800705
CAS No.: 1006592-61-5
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Tamra azide is an azide-terminated fluorescent dye and click reaction partner. Tamra azide undergoes Cu I-catalyzed cycloaddition click reaction with alkyne-functionalized nanodiamonds. After conjugation with nanodiamonds, Tamra azide serves as a fluorescent label that can be excited at a specific wavelength to exhibit characteristic luminescence (Ex/Em=555/580 nm) .
Cat. No.: HY-D1320
CAS No.: 1267539-32-1
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Cyanine5 azide chloride is a Fluorescent probe for cell-selective bacterial protein labeling, as well as a fluorescent dye for single-molecule imaging and dynamic tracking of intracellular organelles. Cyanine5 azide chloride can conjugate with the alkynyl side chain of propargylglycine incorporated into bacterial proteins by the engineered methionyl-tRNA synthetase variant PraRS via copper (I)-catalyzed azide-alkyne [3+2] cycloaddition reaction, thereby enabling in-gel fluorescent visualization of labeled proteins. Cyanine5 azide chloride can diffuse across cell membranes and undergo copper-free click reaction with DBCO-functionalized scAVD pre-bound to DBCO-functionalized biotin, forming fluorescent nanoprobes with enhanced brightness, photostability and localization accuracy, and exhibiting discrete photobleaching steps. The excitation wavelength of Cyanine5 azide chloride is Ex = 633 nm .
Cat. No.: HY-W879007
Synonyms: 5-Azidovaleric acid
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5-Azidopentanoic acid (5-Azidovaleric acid) is a crosslinker/cyclization reagent as well as an azido-containing carboxylic acid. 5-Azidopentanoic acid participates in Cu I-catalyzed azide-alkyne cycloaddition reactions; when used to cap the N-terminus of resin-bound peptides containing propargylglycine residues, it enables head-to-tail cyclodimerization of peptides. 5-Azidopentanoic acid introduces azido functional groups into chitosan via amidation for strain-promoted azide-alkyne cycloaddition click reactions. 5-Azidopentanoic acid acts as an aliphatic bifunctional ligand and capping agent for CdSe tetrapods; its bromo group can be converted to an azido group, which then undergoes catalyst-free alkyne-azide cycloaddition click reactions with ethynyl-terminated poly (3-hexylthiophene) .
Cat. No.: HY-D3521
CAS No.: 1807503-82-7
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Coumarin 343 azide is a fluorescent dye used for the fluorescent labeling of alkyne-containing biomolecules based on click chemistry. Its detection mechanism relies on the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), a type of click reaction: under mild aqueous conditions, the azide group of this dye selectively reacts with the alkyne moiety of propargyl geldanamycin to form a triazole bond that conjugates the fluorescent dye to the target biomolecule; fluorescence is generated upon successful conjugation to the target .
Cat. No.: HY-D3574
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AF488 Picolyl Azide is a Fluorescent dye designed for bioorthogonal visualization applications. AF488 Picolyl Azide functions via copper (I)-catalyzed azide-alkyne cycloaddition click chemistry, where its azide group undergoes covalent reaction with alkyne-functionalized molecules to form fluorescent triazole conjugates. AF488 Picolyl Azide enables the visualization of metabolically labeled isoprenoids in bacteria, which localize to the cell membrane and division septum .
Cat. No.: HY-D3577
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AF555 Picolyl Azide is a Fluorescent dye that enables site-specific fluorescent labeling via click chemistry. AF555 Picolyl Azide conjugates with the non-canonical amino acid N-propargyl-L-lysine introduced through ochre stop codon suppression via the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, achieving labeling of hyperpolarization-activated cyclic nucleotide-gated HCN channels; its picolyl group accelerates the CuAAC reaction rate, thus completing labeling rapidly at room temperature and minimizing copper-induced cytotoxicity. AF555 Picolyl Azide forms covalent bonds with the alkynyl groups of nucleotide analogs through its azide moiety, labeling viral genomes containing 5-ethynyl-2'-deoxyuridine for visualization via fluorescence microscopy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
