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degradation kinetics

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By Targets:	Biochemical Assay Reagents (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) Microtubule/Tubulin (1) PROTACs (1)
By Research Areas:	Cancer (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W110929

Acid blue 1 Xylene blue; C.I. Acid blue 1	Environmental Pollutants Biochemical Assay Reagents	Others
Acid blue 1 (Xylene blue) is an anionic triarylmethane dye and substrate for photocatalytic degradation .

HY-174210

PROTAC BRD4 Degrader-31	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-31 is a BRD4 PROTAC degrader with DC₅₀ s of 164 and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-31 potently degrades BRD4 in cells with long acting degradation kinetics . Pink: BRD4 ligand (HY-78695); Blue: KLHDC2 ligand (HY-174218)

HY-158220C

Hyaluronic acid methacryloyl (MW 50000) HAMA (MW 50000)	Biochemical Assay Reagents	Others
Hyaluronic acid methacryloyl (HAMA) (MW 50000) is a methacrylate-modified hyaluronic acid that serves as a hydrogel former, hydrolysis-resistant material, photocrosslinkable hydrogel scaffold, and drug delivery carrier for tissue engineering. Hyaluronic acid methacryloyl (MW 50000) forms hydrogels via photocrosslinking; when combined with AuMA NPs through a one-step photocrosslinking method, its effective swelling ratio increases, and the mechanical reinforcement effect of Au NPs compensates for the impact caused by reduced crosslinking density. Hyaluronic acid methacryloyl (MW 50000) can be combined with AuMA NPs via a one-step photocrosslinking method, enabling non-invasive monitoring of hydrogel degradation with contrast-enhanced micro-CT .

HY-125374A

Larotaxel dihydrate XRP9881 dihydrate	Microtubule/Tubulin	Cancer
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .

Cat. No.	Product Name

HY-L214

Liposome Library	191 compounds
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 191 liposome compounds, which is a good tool for lipidomic-related studies.

Liposome Library

191 compounds

Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.

MCE contains 191 liposome compounds, which is a good tool for lipidomic-related studies.

Cat. No.	Product Name	Type

HY-W110929

Acid blue 1 Xylene blue; C.I. Acid blue 1	Biochemical Assay Reagents
Acid blue 1 (Xylene blue) is an anionic triarylmethane dye and substrate for photocatalytic degradation .

HY-158220C

Hyaluronic acid methacryloyl (MW 50000) HAMA (MW 50000)	Biochemical Assay Reagents
Hyaluronic acid methacryloyl (HAMA) (MW 50000) is a methacrylate-modified hyaluronic acid that serves as a hydrogel former, hydrolysis-resistant material, photocrosslinkable hydrogel scaffold, and drug delivery carrier for tissue engineering. Hyaluronic acid methacryloyl (MW 50000) forms hydrogels via photocrosslinking; when combined with AuMA NPs through a one-step photocrosslinking method, its effective swelling ratio increases, and the mechanical reinforcement effect of Au NPs compensates for the impact caused by reduced crosslinking density. Hyaluronic acid methacryloyl (MW 50000) can be combined with AuMA NPs via a one-step photocrosslinking method, enabling non-invasive monitoring of hydrogel degradation with contrast-enhanced micro-CT .

Hyaluronic acid methacryloyl (MW 50000)

HAMA (MW 50000)

Biochemical Assay Reagents

Hyaluronic acid methacryloyl (HAMA) (MW 50000) is a methacrylate-modified hyaluronic acid that serves as a hydrogel former, hydrolysis-resistant material, photocrosslinkable hydrogel scaffold, and drug delivery carrier for tissue engineering. Hyaluronic acid methacryloyl (MW 50000) forms hydrogels via photocrosslinking; when combined with AuMA NPs through a one-step photocrosslinking method, its effective swelling ratio increases, and the mechanical reinforcement effect of Au NPs compensates for the impact caused by reduced crosslinking density. Hyaluronic acid methacryloyl (MW 50000) can be combined with AuMA NPs via a one-step photocrosslinking method, enabling non-invasive monitoring of hydrogel degradation with contrast-enhanced micro-CT .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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