Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
dystonia
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "dystonia" in MCE Product Catalog:
5
5 Cited Publications
Target:
Research Areas:
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .
3
Target:
Research Areas:
Trihexyphenidyl hydrochloride is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl hydrochloride modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl hydrochloride improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl hydrochloride can be used for the research of Parkinson's disease. .
2
Target:
Research Areas:
Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .
1
Target:
Research Areas:
VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, Parkinson's disease, and dystonia .
Target:
Research Areas:
Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .
Cat. No.: HY-18159
CAS No.: 1025007-04-8
Synonyms: AZD1446
Target:
Research Areas:
TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder .
Cat. No.: HY-12347R
CAS No.: 199666-03-0
Target:
Research Areas:
Ro 61-8048 (Standard) is the analytical standard of Ro 61-8048. This product is intended for research and analytical applications. Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .
Target:
Research Areas:
Tolperisone (hydrochloride) (Standard) is the analytical standard of Tolperisone (hydrochloride). This product is intended for research and analytical applications. Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .
Research Areas:
Trihexyphenidyl hydrochloride (Standard) is the analytical standard of Trihexyphenidyl hydrochloride (HY-B1277). This product is intended for research and analytical applications. Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .
Cat. No.: HY-182384
CAS No.: 2264025-00-3
Target:
Research Areas:
VU6015241 is a selective, blood-brain barrier-permeable M4 mAChR Antagonist with a Ki value of 43.3 nM. VU6015241 is used for the research of dystonia and related movement disorders .
Cat. No.: HY-P73563A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TH; TYH; Tyrosine Hydroxylase; dystonia 14; Tyrosine 3-Monooxygenase; TH Protein; DYT5b; DYT14; Tyrosine 3-Hydroxylase
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-113057R
CAS No.: 14292-26-3
Cat. No.: HY-B1139S
CAS No.: 1185160-65-9
Cat. No.: HY-108234R
CAS No.: 1135243-19-4
Synonyms: VU 255035 (Standard)
Target:
Research Areas:
VU 0255035 (Standard) is the analytical standard of VU 0255035 (HY-108234). This product is intended for research and analytical applications. VU0255035 is a highly selective and competitive M1 mAChR antagonist. VU0255035 blocks M1 mAChR signals to reduce epileptic seizures and regulate neuronal membrane potential. VU0255035 can be used in research related to central nervous system diseases, such as epilepsy, ParKinson's disease, and dystonia .
Cat. No.: HY-P703199
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SLC2A1; HepG2 Glucose Transporter; Prev. GLUT1; dystonia Gene 9; Prev. HTLVR; Solute Carrier Family 2, Facilitated Glucose Transporter Member 5; Prev. GLUT; Solute Carrier Family 2 Facilitated Glucose Transporter Member 1; Prev. CSE; Glucose Transporter T
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703198
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SLC2A1; HepG2 Glucose Transporter; Prev. GLUT1; dystonia Gene 9; Prev. HTLVR; Solute Carrier Family 2, Facilitated Glucose Transporter Member 5; Prev. GLUT; Solute Carrier Family 2 Facilitated Glucose Transporter Member 1; Prev. CSE; Glucose Transporter T
Species:
Human
Source:
Sf9 insect cells
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
