Torsin 1A Antibody (YA9678)
(Synonyms: DQ2, Dystonia 1, Dystonia 1 protein, Dystonia 1 torsion, Dyt1, TOR1A, TOR1A_HUMAN, Torsin 1A, Torsin A, Torsin family 1 member A)Torsin 1A Antibody (YA9678) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Torsin 1A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
Torsin 1A Antibody (YA9678) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Torsin 1A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 38 kDa;
Synthetic peptide of human Torsin A) DYT1 (aa 283-332).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Torsin 1A is a Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues
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Subcellular Localization
Endoplasmic reticulum lumen; Nucleus membrane; Cell projection, growth cone; Cytoplasmic vesicle membrane; Cytoplasmic vesicle, secretory vesicle; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle; Cytoplasm, cytoskeleton
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Expression
Tissue_Specificity: Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord. -
Isoforms & Post-Translational Modification
Torsin 1A has 2 isoforms, O14656-1: amino acid length is 332, molecular weight is 37809 Da (predicted); O14656-2: amino acid length is 197, molecular weight is 22135 Da (predicted).N-glycosylated
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Subunit
Homohexamer.
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SwissProt ID
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Synonyms
DQ2, Dystonia 1, Dystonia 1 protein, Dystonia 1 torsion, Dyt1, TOR1A, TOR1A_HUMAN, Torsin 1A, Torsin A, Torsin family 1 member A
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