6 Results for "

emtansine

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "emtansine" in MCE Product Catalog:

8
8 Publications Verification
Referencia número: HY-P9921
No. CAS: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine; PRO132365; T-DM 1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer .
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8
8 Publications Verification
Referencia número: HY-P9921A
No. CAS: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine (solution) ; PRO132365 (solution) ; T-DM 1 (solution)
Áreas de investigación:  

Cancer

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer .
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1
1 Cited Publications
Referencia número: HY-P99374
No. CAS: 1622327-39-2
Synonyms: Anti-TSPAN26/CD37 Reference Antibody (naratuximab)

Target:  

ADC Antibodies

Áreas de investigación:  

Cancer

Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine .
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Referencia número: HY-P99685
No. CAS: 1622327-37-0
Synonyms: IMGN-289; J2898A-SMCC-DM1

Áreas de investigación:  

Cancer

Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research .
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Referencia número: HY-132260
No. CAS: 1607824-64-5
Synonyms: IMGN529; Debio 1562

Áreas de investigación:  

Cancer

Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis .
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Referencia número: HY-185495
No. CAS: 1884642-01-6
Target:  

ADC Linkers

Áreas de investigación:  

Cancer

seco-CBI-PBD-disulfide linker is a conjugate of an ADC drug toxin molecule and a linker, consisting of two potent DNA-damaging moieties seco-CBI, PBD (HY-101127), and a disulfide linker .
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