5 Results for "

erythrocytic stage

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "erythrocytic stage" in MCE Product Catalog:

Cat. No.: HY-155354
CAS No.: 3053680-00-2
Purity:  99.13%
Target:  

Parasite

Research Areas:  

Infection

Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .
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Cat. No.: HY-10852A
CAS No.: 959520-73-1
Synonyms: OZ 277 maleate; RBx 11160 maleate
Target:  

Parasite

Research Areas:  

Infection

Arterolane (OZ 277) (maleate) is an orally active antimalarial. Arterolane exhibits potent activity against erythrocytic stages of P. falciparum and Plasmodium vivax. Arterolane (maleate) is promising for research of falciparum malaria .
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Cat. No.: HY-123331
CAS No.: 90832-34-1
Target:  

Parasite

Research Areas:  

Infection

S 82-5455 is a floxacrine derivative that exhibits high activity against drug-susceptible strains of Plasmodium berghei induced in mouse and rat blood .
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Cat. No.: HY-153547
CAS No.: 2521791-38-6
Target:  

Parasite

Research Areas:  

Infection Inflammation/Immunology

HSP90-IN-21 (5e) is an antiplasmodial agent, with IC50 values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .
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Cat. No.: HY-P6300
CAS No.: 169062-92-4
Target:  

Bacterial Parasite

Research Areas:  

Infection

Cyclomarin A is an antibacterial agent with a Kd of 2.3 nM against Mycobacterium tuberculosis ClpC1, a Kd of 2.2 nM against ClpC2, and an IC50 of 0.004 μM against Plasmodium falciparum PfAp3Aase. Cyclomarin A binds to the N-terminal domain of ClpC1, stimulates ATPase and proteolytic activities, dysregulates proteolysis, and induces proteome imbalance; it also binds to ClpC2 and upregulates its transcription level. Cyclomarin A binds to PfAp3Aase in dimeric form, blocks the substrate-binding pathway, inhibits the growth of Plasmodium falciparum in the erythrocytic stage, and shows no activity against human cells. Cyclomarin A exhibits moderate cytotoxicity against a variety of cancer cell lines. Cyclomarin A can serve as a lead compound for the development of Homo-BacPROTAC. Cyclomarin A is applicable to research related to tuberculosis and malaria .
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