959520-73-1
Chemical Structure
Arterolane maleate
Synonym(s): OZ 277 maleate; RBx 11160 maleate
- CAS No.: 959520-73-1
- Formula:C26H40N2O8
- Molecular Weight:508.60
IUPAC Name: N-(2-amino-2-methylpropyl)-2-((1R,3R,4''S,5R,5's,7R)-dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)acetamide maleate
InChIKey: SVDSPJJUJMMDFX-CBAVETRISA-N
SMILES: O=C(NCC(N)(C)C)C[C@H](CC1)CC[C@]21OO[C@]3(O2)[C@H]4C[C@@H]5C[C@H](C4)C[C@H]3C5.O=C(O)/C=C\C(O)=O
Biological Activity: Arterolane (OZ 277) (maleate) is an orally active antimalarial. Arterolane exhibits potent activity against erythrocytic stages of P. falciparum and Plasmodium vivax. Arterolane (maleate) is promising for research of falciparum malaria[1][2].
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Arterolane maleate | Arterolane (OZ 277) (maleate) is an orally active antimalarial. Arterolane exhibits potent activity against erythrocytic stages of P. falciparum and Plasmodium vivax. Arterolane (maleate) is promising for research of falciparum malaria. | |||||||||||||||||||||
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- [1]. Toure OA, et al. A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa. Clin Infect Dis. 2016 Apr 15;62(8):964-971. [Content Brief]
- [2]. Toure OA, et al. Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study. Malar J. 2015 Nov 25;14:469. [Content Brief]
Keywords
