8 Results for "

eukaryotic tRNAs

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "eukaryotic tRNAs" in MCE Product Catalog:

4
N2,N2-Dimethylguanosine
N2,N2-Dimethylguanosine
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4 Cited Publications
Cat. No.: HY-113137
CAS No.: 2140-67-2
Purity:  99.40%
Category:  

Natural Products Other disease Disease markers Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite

N2,N2-Dimethylguanosine is a methylated modified nucleoside present in RNA and serves as a structural modification component of tRNA. N2,N2-Dimethylguanosine inhibits reverse transcriptase-mediated cDNA synthesis and is one of the key modifications affecting sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can be selectively demethylated at one methyl group by AlkB mutant enzymes (such as D135S/L118V) and converted to N2-methylguanosine, thereby reducing the inhibition of reverse transcription .
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3
1-Methylinosine
1-Methylinosine
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3 Cited Publications
Cat. No.: HY-113139
CAS No.: 2140-73-0
Purity:  99.89%
Synonyms: N1-Methylinosine
Category:  

Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Nucleoside Antimetabolite/Analog Endogenous Metabolite

1-Methylinosine (N1-MetHYlinosine) is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models .
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1
Queuine
Queuine
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1 Cited Publications
Cat. No.: HY-N10574
CAS No.: 72496-59-4
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Bacterial

Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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1
N2-Methylguanosine
N2-Methylguanosine
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1 Cited Publications
Cat. No.: HY-111647
CAS No.: 2140-77-4
Purity:  98.03%
Target:  

Nucleoside Antimetabolite/Analog Endogenous Metabolite

Research Areas:  

Others

N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA .
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1
Queuine dihydrochloride
Queuine dihydrochloride
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1 Cited Publications
Cat. No.: HY-N10574A
CAS No.: 86496-18-6
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Others

Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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1-Methylinosine-d3
1-Methylinosine-d3
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Cat. No.: HY-113139S
Purity:  ≥99.0%
Synonyms: N1-Methylinosine-d3
1-Methylinosine-d3 (N1-MetHYlinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models.
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N2-Methylguanosine-d3
N2-Methylguanosine-d3
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Cat. No.: HY-111647S1
N2-Methylguanosine-d3 is deuterium labeled N2-Methylguanosine (HY-111647). N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA .
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N2-Methylguanosine (Standard)
N2-Methylguanosine (Standard)
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Cat. No.: HY-111647R
CAS No.: 2140-77-4
Category:  

Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite

N2-Methylguanosine (Standard) is the analytical standard of N2-Methylguanosine (HY-111647). This product is intended for research and analytical applications. N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA .
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