2140-73-0
Chemical Structure
1-Methylinosine
Synonym(s): N1-Methylinosine
- CAS No.: 2140-73-0
- Formula:C11H14N4O5
- Molecular Weight:282.25
IUPAC Name: 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-methyl-1,9-dihydro-6H-purin-6-one
InChIKey: WJNGQIYEQLPJMN-IOSLPCCCSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN(C)C3=O)=C3N=C2)O1
Biological Activity: 1-Methylinosine (N1-MetHYlinosine) is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models[1][2].
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1-Methylinosine | 99.72% | 1-Methylinosine (N1-MetHYlinosine) is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models. | ||||||||||||||||||||
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1-Methylinosine-d3 | 99.0% | 1-Methylinosine-d3 (N1-MetHYlinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models. | ||||||||||||||||||||
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References
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[1]. Tormey DC, et al. Biological markers in breast carcinoma—clinical correlations with pseudouridine, n2, N2‐dimethylguanosine, and 1‐methylinosine. Journal of surgical oncology. 1980 Jul;14(3):267-73.
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[2]. Dutta SP, Chheda GB. Metabolism of 1-methyladenosine. Biochem Med Metab Biol. 1987 Aug;38(1):69-73.
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