Metabolism of 1-methyladenosine

  • Biochem Med Metab Biol. 1987 Aug;38(1):69-73. doi: 10.1016/0885-4505(87)90063-6.
S P Dutta  1 ,  G B Chheda
Affiliations
  • 1. Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York 14263.
PMID: 3663399 DOI: 10.1016/0885-4505(87)90063-6
Abstract

1-[methyl-8-14C] Adenosine was synthesized and its metabolic fate was determined in intact rat. It was found that approximately 57% of 1-[methyl-8-14C] adenosine administered iv was excreted unchanged in the urine and 33% of the excreted radioactivity in the urine was associated with the major metabolite 1-methyl-hypoxanthine and about 4.5% was associated with 1-methylinosine. Very little adenosine or N6-methyladenosine was formed. It is concluded that 1-methyladenosine is initially deaminated by Adenosine Deaminase to 1-methylinosine which is then cleaved by nucleoside Phosphorylase to 1-methylhypoxanthine.

Products