2140-67-2
2140-67-2
Chemical Structure
N2,N2-Dimethylguanosine
- CAS No.: 2140-67-2
- Formula:C12H17N5O5
- Molecular Weight:311.29
IUPAC Name: 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-(dimethylamino)-1,9-dihydro-6H-purin-6-one
InChIKey: RSPURTUNRHNVGF-IOSLPCCCSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C=N2)C3=C2C(NC(N(C)C)=N3)=O)O1
Biological Activity: N2,N2-Dimethylguanosine is a methylated modified nucleoside present in RNA and serves as a structural modification component of tRNA. N2,N2-Dimethylguanosine inhibits reverse transcriptase-mediated cDNA synthesis and is one of the key modifications affecting sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can be selectively demethylated at one methyl group by AlkB mutant enzymes (such as D135S/L118V) and converted to N2-methylguanosine, thereby reducing the inhibition of reverse transcription[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
N2,N2-Dimethylguanosine | 99.40% | N2,N2-Dimethylguanosine is a methylated modified nucleoside present in RNA and serves as a structural modification component of tRNA. N2,N2-Dimethylguanosine inhibits reverse transcriptase-mediated cDNA synthesis and is one of the key modifications affecting sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can be selectively demethylated at one methyl group by AlkB mutant enzymes (such as D135S/L118V) and converted to N2-methylguanosine, thereby reducing the inhibition of reverse transcription. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N2,N2-Dimethylguanosine (Standard) | ≥98% | N2,N2-Dimethylguanosine (Standard) is the analytical standard of N2,N2-Dimethylguanosine. This product is intended for research and analytical applications. N2,N2-Dimethylguanosine is an urinary nucleoside, a primary degradation product of tRNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N2-Methylguanosine (Standard) | ≥98% | N2-Methylguanosine (Standard) is the analytical standard of N2-Methylguanosine (HY-111647). This product is intended for research and analytical applications. N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N2-Ethylguanosine | N2-Ethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
9-(β-D-Xylofuranosyl)guanine | 9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2’-Deoxy-N2,N2-dimethylguanosine | 2’-Deoxy-N2,N2-dimethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Alpha-Guanosine | 99.91% | Alpha-Guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Guanosine | 99.23% | Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
9-β-D-Arabinofuranosylguanine | 99.77% | 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Guanosine-15N5 | 99.6% | Guanosine-15N5 is the 15N labeled Guanosine. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Guanosine-13C10,15N5 | 99.9% | Guanosine-13C10,15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Guanosine-13C5 | Guanosine-13C5 is a deuterated labeled Guanosine. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pallan PS, et al. Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs. RNA. 2008 Oct;14(10):2125-35. [Content Brief]
- [2]. Dai Q, et al. Selective Enzymatic Demethylation of N2 ,N2 -Dimethylguanosine in RNA and Its Application in High-Throughput tRNA Sequencing. Angew Chem Int Ed Engl. 2017;56(18):5017-5020. [Content Brief]
