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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
fgf21+inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "fgf21+inhibitor" in MCE Product Catalog:
1
1 Cited Publications
FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC50: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect .
Synonyms: fgfR irreversible inhibitor-1
FIIN-1 is a potent, irreversible, selective FGFR inhibitor. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC50s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively .
Cat. No.: HY-139376
CAS No.: 2410612-08-5
FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer .
Cat. No.: HY-158098
CAS No.: 2157482-40-9
Target:
Research Areas:
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity .
Cat. No.: HY-169710
CAS No.: 606958-57-0
FGFR1 inhibitor-16 (Compound 89) is an FGFR1 inhibitor. FGFR1 inhibitor-16 exhibits an inhibitory rate of 53.00% against FGFR1 at a concentration of 50 μM and 24.95% at 10 μM. FGFR1 inhibitor-16 can be used in the study of cancer .
Cat. No.: HY-W261325
CAS No.: 459137-97-4
FGFR1 inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer .
Cat. No.: HY-W801893
CAS No.: 670266-26-9
FGFR1 inhibitor-13 (compound 1) is an FGFR1 inhibitor with an IC50 of 4.2 μM .
Cat. No.: HY-169623
CAS No.: 442534-83-0
FGFR1 inhibitor-14 (compound 28) is a FGFR1 inhibitor, which can be used in anti-cancer research .
Cat. No.: HY-169669
CAS No.: 308298-51-3
FGFR1 inhibitor-17 (Compound 92) is a potent FGFR1 inhibitor. FGFR1 inhibitor-17 is promising for research of cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
