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Cat. No.: HY-172618

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FGFR1 inhibitor-18

FGFR1 inhibitor-18 (compound 16) is a potent FGFR1 inhibitor with an IC₅₀ value of 1.31 nM. FGFR1 inhibitor-18 can occupy within the ATP-binding pocket of the target FGFR1.

For research use only. We do not sell to patients.

Formula: C₂₆H₁₇ClN₄O₃
Molecular Weight:468.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

FGFR1 inhibitor-18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

FGFR1 inhibitor-18 (compound 16) is a potent FGFR1 inhibitor with an IC₅₀ value of 1.31 nM. FGFR1 inhibitor-18 can occupy within the ATP-binding pocket of the target FGFR1^[1].

IC₅₀ & Target

^[1]

FGFR1

1.31 nM (IC₅₀)

Chemical Information

Molecular Weight 468.89
Formula C₂₆H₁₇ClN₄O₃
SMILES

O=C1C(Cl)=C(NC2=CC(C3=CN(C4=CC=C(C(C)=O)C=C4)N=N3)=CC=C2)C(C5=CC=CC=C51)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ronnakorn Leechaisit, et al. Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Naphthoquinone-Triazole Hybrids as Potential FGFR1 Tyrosine Kinase Inhibitors. Asian Journal of Organic Chemistry, 2025: e202400813.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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