FGFR1 inhibitor-11
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity.
For research use only. We do not sell to patients.
- CAS No.: 2157482-40-9
- Formula: C23H18O4
- Molecular Weight:358.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
2.387 μM
Compound: 5g
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Anti-osteoclastogenic activity in C57/BL6 mouse BMDM cells assessed as inhibition of RANKL-induced osteoclast differentiation by measuring number of TRAP-positive cells incubated for 4 days in presence of M-CSF by TRAP staining based microscopic analysis
Anti-osteoclastogenic activity in C57/BL6 mouse BMDM cells assessed as inhibition of RANKL-induced osteoclast differentiation by measuring number of TRAP-positive cells incubated for 4 days in presence of M-CSF by TRAP staining based microscopic analysis
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[PMID: 38555854] |
FGFR1 inhibitor-11 (compound 5g) (0-20μM, 4 Days) attenuated RANKL-induced osteoclastogenesis in bone marrow-derived macrophages[1].
FGFR1 inhibitor-11 (0-160 μM; 48 h) shows no significant toxicity in BMDMs below 20 μM[1].
FGFR1 inhibitor-11 (0-10 μM) inhibits the formation of the F-actin belts[1].
FGFR1 inhibitor-11 (0-10 μM) suppresses osteoclastogenesis by reducing NFATc1 and c-fos to inhibit the expressions of the genes that are required for osteoclastogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BMDMs
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Concentration:0, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 160 μM
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Incubation Time:48 h
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Result:Had toxicity in BMDMs above 40 μM.
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Cell Line:Osteoclasts
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Concentration:0, 2.5μM, 5 μM, 10 μM
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Incubation Time:
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Result:Showed significantly and dose dependently the protein level of F-actin.
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Cell Line:BMDMs
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Concentration:10 μM
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Incubation Time:1 day, 2 days, 3 days
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Result:Showed inhibition of the mRNA expression level (Ctsk, Mmmp9 and so on) of the main osteoclast-specific marker genes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2157482-40-9
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Molecular Weight 358.39
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Formula C23H18O4
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SMILES
COC1=CC=C(C=C1)C2=C(C(C3=CC=CC=C3O2)=O)CC4=C(C=CC=C4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGFR1 inhibitor-11 Related Classifications
HY-158098 Related Classifications
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