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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
fibrinogen receptor
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "fibrinogen receptor" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-114164H
CAS No.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Research Areas:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
6
Target:
Research Areas:
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
6
6 Cited Publications
Cat. No.: HY-17369
CAS No.: 150915-40-5
Synonyms: L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate
Target:
Research Areas:
Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
3
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2
2 Cited Publications
Cat. No.: HY-P7507
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ANGPTL4; Peroxisome Proliferator-Activated receptor (PPAR) Gamma Induced Angiopoietin-Related Protein; Angiopoietin Like 4; Hepatic Angiopoietin-Related Protein; HFARP; PPARG Angiopoietin Related Protein; PGAR; Fasting-Induced Adipose Factor; ARP4; Angiopoietin-Like Protein 4; Hepatic fibrinogen/Angiopoietin-Related Protein; Angiopoietin-Like 4; Angiopoietin-Related Protein 4; UNQ171; Pp1158; TGQTL; FIAF; HARP; NL2
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-114164G
CAS No.: 9002-04-4
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus .
1
1 Cited Publications
Cat. No.: HY-P1741
CAS No.: 137235-80-4
Target:
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1
1 Cited Publications
Cat. No.: HY-P1741A
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P77716
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: ITGA2B; Platelet fibrinogen receptor, Alpha Subunit; Prev. GP2B; Platelet Glycoprotein IIb; GPIIb; AlphaIIb Protein; Integrin Alpha-IIb; Glycoprotein IIb; PPP1R93; CD41 Antigen; CD41B; BDPLT16; CD41; BDPLT2; Integrin, Alpha 2b (Platelet Glycoprotein IIb O
Species:
Human
Source:
HEK293
Cat. No.: HY-P5098
CAS No.: 250612-47-6
Target:
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Cat. No.: HY-120694
CAS No.: 1355454-05-5
Synonyms: RUC-2
Target:
Research Areas:
ML165 (RUC-2) is an aIIbb3 receptor antagonist. ML165 has orthosteric inhibition effect at the RGD binding domain. ML165 inhibits platelet adhesion to fibrinogen, and inhibits platelet aggregation (IC50: 96 nM) .
Cat. No.: HY-17369A
CAS No.: 142373-60-2
Synonyms: L700462 hydrochloride; MK383 hydrochloride
Target:
Research Areas:
Tirofiban (L700462) hydrochloride is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
Cat. No.: HY-17369BR
CAS No.: 144494-65-5
Synonyms: L700462 (Standard); MK383 (Standard)
Target:
Research Areas:
Tirofiban (Standard) is the analytical standard of Tirofiban. This product is intended for research and analytical applications. Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
Cat. No.: HY-P3531
CAS No.: 80755-86-8
Cat. No.: HY-106932
CAS No.: 146144-48-1
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Research Areas:
L-734217 is an orally active and potent fibrinogen receptor antagonist and an antithrombotic agent. L-734217 is excreted largely by the renal route and partly into the bile in dogs. L-734217 is promising for research of thrombotic disorders .
Cat. No.: HY-10315
CAS No.: 198958-88-2
Synonyms: RWJ-53308
Target:
Research Areas:
Elarofiban (RWJ-53308) is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban has the potential for platelet mediated thrombotic disorders research .
Cat. No.: HY-10315A
CAS No.: 198958-89-3
Target:
Research Areas:
Elarofiban diTFA is the salt form of Elarofiban (HY-10315) with two TFA. Elarofiban diTFA is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban diTFA has the potential for platelet mediated thrombotic disorders research .
Cat. No.: HY-119238
CAS No.: 256385-24-7
Target:
Research Areas:
CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies .
Cat. No.: HY-135568
CAS No.: 256344-23-7
Target:
Research Areas:
CRL-42872 free base is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 free base inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 free base is widely used in thrombosis-related studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
