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Results for "

flavonoid derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (4) Akt (2) Aldose Reductase (1) Apoptosis (7) Bacterial (7) Biochemical Assay Reagents (1) Calcium Channel (2) Caspase (1) ClpP (2) COX (4) Endogenous Metabolite (2) ERK (2) Fungal (2) Glycosidase (1) HBV (1) Interleukin Related (3) JNK (3) NF-κB (2) p38 MAPK (2) PARP (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (4) Reference Standards (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Infection (8) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (3)

Inhibitors & Agonists

Bibliotecas de Screening

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N1181

Tamarixetin 2 Publications Verification 4'-O-Methyl Quercetin	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-N6605

Kaempferol 3-O-β-D-galactopyranoside 1 Publications Verification Trifolin	Apoptosis	Cardiovascular Disease Cancer
Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is an orally active flavonoid derivative that can be found in the aerial parts of Consolida oliverana. Kaempferol 3-O-β-D-galactopyranoside exhibits antitumor and cardioprotective effects .

HY-106449

Recoflavone DA-6034 free acid	NF-κB COX Apoptosis ERK Calcium Channel	Inflammation/Immunology Cancer
Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca( ²⁺)]_i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury .

HY-151231

6-Hydroxyluteolin	Aldose Reductase	Neurological Disease Metabolic Disease
6-Hydroxyluteolin (Compound 17) is a flavonoid derivative and also an inhibitor of Aldose reductase, with an experimental -log IC₅₀ value of 6.690. 6-Hydroxyluteolin can be isolated from the leaves of multiple plant families, including Plantaginaceae, Globulariaceae and Labiatae. 6-Hydroxyluteolin serves as a phylogenetic marker for higher plants. 6-Hydroxyluteolin can be used in the research of diabetic cataract .

HY-N8920

Syringetin	Others	Metabolic Disease
Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts .

HY-N11658

p-Coumaroyl-CoA 4-Coumaroyl-CoA; p-coumaroylcoenzyme A	Biochemical Assay Reagents	Others
p-Coumaroyl-CoA (4-Coumaroyl-CoA; p-coumaroylcoenzyme A) is a coenzyme A derivative . p-Coumaroyl-CoA serves as a key intermediate in the biosynthesis of lignin and flavonoids .

HY-N2054

Kaempferol 4'-glucoside Kaempferol 4'-β-glucoside	Drug Derivative	Others
Kaempferol 4'-glucoside (Kaempferol 4'-β-glucoside) is a glycosylated form of Kaempferol (HY-14590). Kaempferol 4'-glucoside interacts with SBE-β-CD (HY-17031). Kaempferol 4'-glucoside can be used in the food and active compound industries .

HY-N0172S

Caffeic acid-13C3 3,4-Dihydroxycinnamic acid-¹³C₃	Bacterial Fungal	Infection
Caffeic acid- ¹³C₃ is an ¹³C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .

HY-148560B

cis-ccc_R08	HBV	Infection
cis-ccc_R08 (compound 1) is a flavonoid derivative that can be used in the study of hepatitis B virus (HBV) infection. cis-ccc_R08 is a cccDNA (covalently closed circular DNA) inhibitor .

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Bacterial	Infection Inflammation/Immunology
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

HY-N2857

Alpinumisoflavone	Others	Others
Alpinumisoflavone (compound 2) is a flavonoid derivative isolated from the stem bark of Erythrina lysistemon Hutch .

HY-N1181R

Tamarixetin (Standard) 4'-O-Methyl Quercetin (Standard)	Reference Standards Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-W510941

Hesperetin dihydrochalcone	Drug Derivative	Others
Hesperetin dihydrochalcone is a flavonoid derivative with a flavoring activity .

HY-156332

TNKS-2-IN-2	PARP	Cancer
TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC₅₀ of 22 nM .

HY-116135

R24	Apoptosis Reactive Oxygen Species (ROS)	Cancer
R24 is a type of flavonoid derivative. R24 exhibits strong anti-angiogenic and anti-proliferative effects. R24 induces cell apoptosis and promotes the production of reactive oxygen species (ROS). R24 can be used for the study of cancers such as lung cancer and colorectal cancer .

HY-126422

cis-Tiliroside	Others	Cancer
cis-Tiliroside, a kaempferol derivative, is a flavonoid glycoside. cis-Tiliroside exhibits better cytotoxic activity than trans-Tiliroside in A549 cell line .

HY-N7321A

(R)-Eucomol	Bacterial	Infection Cancer
(R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells .

HY-N12669

Curcumin monoglucoside	Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase	Neurological Disease
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-158053

Antifungal agent 94	Fungal	Infection
Antifungal agent 94 (Compound 49) is a Flavonoid derivative, which exhibits antifungal activity with EC₅₀ of 0.28 μM and a half-maximal effective concentration of 0.46 μg/mL against Rhizoctonia solani .

HY-N12309

2′-O-Methylphloretin	Others	Others
2′-O-Methylphloretin (compound 3) is a flavonoid derivative. 2′-O-Methylphloretin can be isolated from the leaves of Melodorum siamensis. 2′-O-Methylphloretin inhibits the tumor cell line replication .

HY-N12138

Flaccidoside III	Glycosidase	Metabolic Disease
Flaccidoside III is a triterpenoid isolated from the aerial parts of N. sativa (Ranunculaceae). Flaccidoside III inhibits α-Glucosidase (IC₅₀: 256.7 μM) and has potential antioxidant and antidiabetic activities .

HY-N8618

Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol	Others	Others
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .

HY-N11464

Kuwanon O	Others	Others
Kuwanon O is a flavonoid derivative with a fused dihydrochalcone partial moiety, that can be isolated from the root bark of Morus lhou (set.) Koidz .

HY-N18765

Dragons blood extract	Bacterial	Infection Inflammation/Immunology
Dragons blood extract contains a variety of bioactive compounds, including alkaloids, flavonoids, phenolic acids, and chalcone derivatives, which have antibacterial, anti-inflammatory, antioxidant, and wound-healing effects.

HY-N18680

Melissa officinalis extract	Others	Neurological Disease
Melissa officinalis extract is rich in various bioactive compounds, such as citronellol, geraniol, glycosides, caffeic acid derivatives, flavonoids, and triterpenoids. Melissa officinalis extract can be used in research on conditions such as nervous tension, anxiety, insomnia, and menstrual disorders.

HY-N11839

Quercetin 7,4′-diglucoside	Drug Derivative	Others
Quercetin 7,4′-diglucoside is a flavonol diglucoside and a derivative of Quercetin (HY-18085) that can be found in Allium cepa L. Quercetin is a natural flavonoid compound that can activate or inhibit the activity of many proteins .

HY-179371

LIQ1	Pyruvate Kinase Interleukin Related	Inflammation/Immunology
LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC₅₀ = 0.39 μM; K_d = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS (HY-D1056)-induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia ^[1].

HY-181638

4-Cl-Benzodioxolyl chalcone	Drug Derivative	Metabolic Disease
4-Cl-Benzodioxolyl chalcone is a type of chalcone. It reduces the viability of endometriotic cells while maintaining or increasing the viability of normal endometrial cells. 4-Cl-Benzodioxolyl chalcone can be used in the research of endometriosis .

HY-106449R

Recoflavone (Standard) DA-6034 free acid (Standard)	Reference Standards NF-κB COX Apoptosis ERK Calcium Channel	Inflammation/Immunology Cancer
Recoflavone (Standard) is the analytical standard of Recoflavone (HY-106449). This product is intended for research and analytical applications. Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury .

Cat. No.	Nombre del producto

HY-L021M

Natural Product and Natural Product-Like Compound Library	5,019 compounds
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Natural Product and Natural Product-Like Compound Library

5,019 compounds

From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.

MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Nombre del producto	Category	Target	Chemical Structure