3 Results for "

guinea-pig isolated right atria

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "guinea-pig isolated right atria" in MCE Product Catalog:

Seglitide
Seglitide
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Cat. No.: HY-106103
CAS No.: 81377-02-8
Purity:  99.30%
Synonyms: MK-678; L-363586
Target:  

Somatostatin Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Seglitide (MK-678) is an orally active, selective SSTR2 agonist and somatostatin analog. Seglitide also acts as a competitive Somatostatin receptor antagonist, with pA2 values of 6.50, 6.24 and 6.09 against SS14, SS25 and SS28, respectively. Seglitide produces only weak, transient inhibition of myocardial contractility in isolated right atria of guinea pigs. Seglitide inhibits glucagon secretion and reduces circulating insulin levels. Seglitide causes a sustained, reversible reduction in elevated systolic blood pressure in streptozotocin (HY-13753)-induced diabetic rats, but exerts no effect on spontaneously hypertensive rats. Seglitide induces membrane hyperpolarization and inhibits electrical excitability. Seglitide induces concentration-dependent contraction and significant desensitization in isolated distal colon of rats. Seglitide can be used in research related to hypertension complicated with insulin-dependent diabetes mellitus .
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Tyr-α-CGRP (human) TFA
Tyr-α-CGRP (human) TFA
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Cat. No.: HY-P2601A
Target:  

CGRP Receptor

Research Areas:  

Others

Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC50 values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC50 values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC50 value of 1.9 nM .
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(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone
(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone
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Cat. No.: HY-N21983
CAS No.: 1932291-56-9
Category:  

Natural Products Chimaphila japonica Miq. Plants Ericaceae

Target:  

Drug Derivative

(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1 (2H)-naphthalenone is a tetralone derivative found in Pyrola calliantha. It exerts extremely weak inhibitory effects on arachidonic acid-induced platelet aggregation and shows no positive inotropic activity on isolated guinea pig right atria .
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