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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
hnRNP
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "hnRNP" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N6796
CAS No.: 52665-74-4
1
1 Cited Publications
Target:
Research Areas:
VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor .
1
1 Cited Publications
Cat. No.: HY-155978A
Purity: 99.80%
Target:
Research Areas:
RDN2150 TFA is a ZAP-70 inhibitor with an IC50 of 14.6 nM, and it exhibits selectivity for Syk over other kinases. RDN2150 TFA inhibits signal transduction and activation of T cells/CAR-T cells, reduces the phosphorylation level of Erk1/2, suppresses the induction of CD69 and IL-2, and downregulates phosphotyrosine signaling pathways including hnRNP sites in T cells. RDN2150 TFA can be used for psoriasis-related research .
1
1 Cited Publications
Cat. No.: HY-P72145
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CIRBP; Glycine-Rich RNA Binding Protein; Cold Inducible RNA Binding Protein; A18 hnRNP; Cold-Inducible RNA-Binding Protein; Cold Inducible RNA-Binding Protein; CIRP; Testicular Tissue Protein Li 39; Glycine-Rich RNA-Binding Protein CIRP; A18hnRNP
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P76261
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CIRBP; Glycine-Rich RNA Binding Protein; Cold Inducible RNA Binding Protein; A18 hnRNP; Cold-Inducible RNA-Binding Protein; Cold Inducible RNA-Binding Protein; CIRP; Testicular Tissue Protein Li 39; Glycine-Rich RNA-Binding Protein CIRP; A18hnRNP
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P72229
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: hnRNPA1; Heterogeneous Nuclear Ribonucleoprotein A1B Protein; Prev. HNRPA1; Nuclear Ribonucleoprotein Particle A1 Protein; hnRNP-A1; Single-Strand DNA-Binding Protein UP1; ALS20; hnRNP Core Protein A1-Like 3; Epididymis Secretory Sperm Binding Protein; Hn
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74649
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCBP1; Nucleic Acid-Binding Protein SUB2.3; Poly(RC) Binding Protein 1; Epididymis Secretory Protein Li 85; Heterogeneous Nuclear Ribonucleoprotein E1; Alpha-CP1; Poly(RC)-Binding Protein 1; HEL-S-85; hnRNP-E1; Heterogenous Nuclear Ribonucleoprotein E1; H
Species:
Human
Source:
E. coli
Cat. No.: HY-P5960
Synonyms: PTBP1 α3-helix derived peptide P6 TFA
Target:
Research Areas:
Cat. No.: HY-126076A
CAS No.: 2410979-04-1
Target:
Research Areas:
VPC-80051 is an inhibitor of hnRNP A1 splicing activity. VPC-80051 directly interacts with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. VPC-80051 can be used in prostate cancer research .
Cat. No.: HY-170964
CAS No.: 1009838-93-0
Target:
Research Areas:
HPH-15 is an anti-migration compound that inhibits cell migration by binding to hnRNP U or suppressing TGF-β signaling. In addition, HPH-15 can also inhibit epithelial-mesenchymal transition (EMT). HPH-15 holds promise for research in the fields of anti-tumor metastasis and anti-fibrosis .
Cat. No.: HY-141878
CAS No.: 2767983-76-4
Target:
Research Areas:
di-Ellipticine-RIBOTAC is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2) exp). di-Ellipticine-RIBOTAC selectively binds the three-dimensional (3D) structure formed by r(G4C2) exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2) exp. di-Ellipticine-RIBOTAC selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2) exp. di-Ellipticine-RIBOTAC significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) .
Cat. No.: HY-155978
CAS No.: 2839429-51-3
Target:
Research Areas:
RDN2150 is a ZAP-70 inhibitor with an IC50 of 14.6 nM, and it exhibits selectivity for Syk over other kinases. RDN2150 inhibits signal transduction and activation of T cells/CAR-T cells, reduces the phosphorylation level of Erk1/2, suppresses the induction of CD69 and IL-2, and downregulates phosphotyrosine signaling pathways including hnRNP sites in T cells. RDN2150 can be used for psoriasis-related research .
Cat. No.: HY-155050
Purity: 99.25%
Target:
Research Areas:
PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min) .
Cat. No.: HY-160049
Research Areas:
BC15 aptamer sodium is an ssDNA aptamer targeting the intracellular protein hnRNP A1, which is highly expressed in cancerous liver tissue. BC15 aptamer sodium specifically recognizes breast cancer cells and can be used to detect cancer cells in other pathological types of breast cancer tissue .
Cat. No.: HY-RS06265
Target:
Research Areas:
HNRNPC Human Pre-designed siRNA Set A contains three designed siRNAs for HNRNPC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06268
Target:
Research Areas:
HNRNPDL Human Pre-designed siRNA Set A contains three designed siRNAs for HNRNPDL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-155051
Target:
Research Areas:
Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes .
Cat. No.: HY-141878A
CAS No.: 2767983-77-5
Target:
Research Areas:
di-Ellipticine-RIBOTAC TFA is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2) exp). di-Ellipticine-RIBOTAC TFA selectively binds the three-dimensional (3D) structure formed by r(G4C2) exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2) exp. di-Ellipticine-RIBOTAC TFA selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2) exp. di-Ellipticine-RIBOTAC TFA significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC TFA can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) .
Cat. No.: HY-182546
CAS No.: 664968-32-5
Target:
Research Areas:
Anticancer agent 312 is a heterogeneous nuclear ribonucleoprotein A18 (hnRNP A18) inhibitor with an IC50 of 2.9 μM. Anticancer agent 312 binds to the RNA recognition motif of hnRNP A18 and blocks its binding to homologous RNA transcripts. Anticancer agent 312 acts as a protein synthesis inhibitor by blocking hnRNP A18-mediated mRNA translation. Anticancer agent 312 is applicable to research on cancers such as melanoma .
Cat. No.: HY-182514
CAS No.: 748785-70-8
BMMP is an anti-HIV-1 agent and hnRNP M modulator. BMMP modulates hnRNP M function to suppress CD44 mRNA expression. BMMP induces abnormal uncoating of the HIV viral core at the post-entry step. BMMP suppresses migration of TGF-β-stimulated lung carcinoma cells. BMMP suppresses HIV-1 reverse transcription and replication without inhibiting virion release. BMMP exerts anti-HIV-1 activity via a mechanism distinct from CA protein-binding heterocyclic compounds. BMMP can be used for the research of human immunodeficiency virus infection and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
