hnRNP
Heterogeneous Ribonucleoprotein
Heterogeneous nuclear ribonucleoprotein (hnRNP) is a group of proteins that bind to pre-mRNA in the nucleus and play a crucial role in various aspects of RNA metabolism. hnRNP proteins are involved in pre-mRNA splicing, where they help to determine the selection of splice sites, leading to alternative splicing events and the generation of different mRNA isoforms. hnRNP also participate in the capping and polyadenylation of pre-mRNA, which are essential for mRNA stability and export from the nucleus. Once the mRNA is mature, hnRNP proteins can bind to it and regulate its transport to the cytoplasm, stability, and translation efficiency. For example, hnRNP A1 can shuttle between the nucleus and the cytoplasm, facilitating mRNA export. Dysregulation of hnRNP functions has been associated with various diseases, including cancer[1][2][3].
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hnRNP Related Products (4)
Related Products (4)
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TDP-43 ligand-1
0 ImagesTDP-43 ligand-1 is a specific ligand for TDP43, and its Ki value for binding to TDP-43 protein aggregates is 78 nM. TDP-43 ligand-1 can be used in the research of PET imaging probes for TDP-43 proteinopathies.
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ACI-19278
0 ImagesACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions.
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BMMP
0 ImagesBMMP is an anti-HIV-1 agent and hnRNP M modulator. BMMP modulates hnRNP M function to suppress CD44 mRNA expression. BMMP induces abnormal uncoating of the HIV viral core at the post-entry step. BMMP suppresses migration of TGF-β-stimulated lung carcinoma cells. BMMP suppresses HIV-1 reverse transcription and replication without inhibiting virion release. BMMP exerts anti-HIV-1 activity via a mechanism distinct from CA protein-binding heterocyclic compounds. BMMP can be used for the research of human immunodeficiency virus infection and non-small cell lung cancer.
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BDF34019555
0 ImagesCat. No.: HY-187172BDF34019555 is a blood-brain barrier-permeable binder targeting the conserved region (amino acid residues 320-340) of TDP-43, with a Kd of 10.4 μM for full-length TDP-43 and 7.8 μM for the CR polypeptide, respectively. BDF34019555 binds to the conserved α-helical region of TDP-43 in a Trp334-dependent manner, inhibits liquid-liquid phase separation, aggregation and mitochondrial localization of TDP-43, restores mitochondrial function, reduces cytoplasmic and insoluble TDP-43 levels, without affecting the splicing activity of TDP-43. BDF34019555 exerts neuroprotective effects, alleviates motor neuron loss and improves motor neuron function. BDF34019555 can be used in studies related to amyotrophic lateral sclerosis.
