TDP-43 ligand-1
Based on 1 publication(s) in Google Scholar
TDP-43 ligand-1 is a specific ligand for TDP43, and its Ki value for binding to TDP-43 protein aggregates is 78 nM. TDP-43 ligand-1 can be used in the research of PET imaging probes for TDP-43 proteinopathies.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 3033951-71-9
- Formula: C20H17F2N5OS
- Molecular Weight:413.44
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications Citing Use of MedChemExpress (MCE) TDP-43 ligand-1
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Biological Activity
TDP-43 ligand-1 (Example 8) can specifically bind to the pathological aggregates of TDP-43 in brain tissues. The replacement values in pathological brain tissues (Type A and Type B) (3.0 and 3.3) are significantly higher than those in the normal control group (2.3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033951-71-9
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Appearance Solid
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Molecular Weight 413.44
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Formula C20H17F2N5OS
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Color Light yellow to yellow
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SMILES
FC1=C(C=CC(N2CC[C@@H](C2)F)=N1)C3=NC(CCN(C4=CN=CC=C4)C5=O)=C5S3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]2025 Dec 12;16(1):11314. PMID: 41387431
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)