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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
homeodomain-interacting protein kinase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "homeodomain-interacting protein kinase" in MCE Product Catalog:
7
2
2 Cited Publications
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy .
Cat. No.: HY-177416
CAS No.: 2624098-97-9
MU1787 is a highly selective homeodomain-interacting protein kinase (HIPK) inhibitor with a furopyridine core, and shows improved selectivity against CLKs, with inactivity against DYRK1B, DYRK2, and MLK2/3 in in vitro cellular assays. MU1787 can be used for the research of malignancies .
BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis .
Cat. No.: HY-E70830
Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals. HIPK2 Recombinant Human Active Protein Kinase is a recombinant HIPK2 protein that can be used to study HIPK2-related functions .
Cat. No.: HY-P811341
Synonyms: homeodomain-interacting protein kinase 4, HIPK4
Cat. No.: HY-P701693
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HIPK1; MGC33446; homeodomain interacting protein kinase 1; MGC33548; KIAA0630; homeodomain interacting protein kinase 1-Like protein; Nbak2; Non-Specific Serine/Threonine protein kinase; Myak; Nuclear Body Associated kinase 2b; homeodomain-interacting Pro
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701694
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HIPK1; MGC33446; homeodomain interacting protein kinase 1; MGC33548; KIAA0630; homeodomain interacting protein kinase 1-Like protein; Nbak2; Non-Specific Serine/Threonine protein kinase; Myak; Nuclear Body Associated kinase 2b; homeodomain-interacting Pro
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706148
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: homeodomain-interacting protein kinase 2; EC:2.7.11.1; hHIPk2; HIPK2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-100464R
CAS No.: 1639895-85-4
Target:
Research Areas:
tBID (Standard) is the analytical standard of tBID (HY-100464). This product is intended for research and analytical applications. tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of 0.33 μM.
Cat. No.: HY-P701698
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HIPK3; YAK1; homeodomain interacting protein kinase 3; Androgen Receptor-interacting Nuclear protein kinase; DYRK6; Fas-interacting Serine/Threonine-protein kinase; FIST3; Homolog Of protein kinase YAK1; PKY; ANPK; homeodomain-interacting protein kinase 3
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-189141
Target:
Research Areas:
HIPK2-IN-2 is an orally active and selective HIPK2 inhibitor with an IC50 of 0.36 μM against HIPK2. HIPK2-IN-2 reduces HIPK2 protein expression levels. HIPK2-IN-2 inhibits the proliferation and migration of renal interstitial fibroblasts, alleviates renal tubular injury and collagen deposition, and suppresses TGF-β/Smad3-mediated profibrotic signaling pathways as well as TNF-α/NF-κB-mediated inflammatory signaling pathways in renal cells. HIPK2-IN-2 is used for the study of chronic kidney disease-associated renal fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
