Search Result

Results for "

human 5-HT6 receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (23) Adenylate Cyclase (1) Adrenergic Receptor (3) Apoptosis (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) FAAH (1) G protein-coupled Bile Acid Receptor 1 (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3)
By Research Areas:	Cancer (2) Metabolic Disease (1) Neurological Disease (20)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14336A

SB 271046 Hydrochloride SB 271046A	5-HT Receptor	Neurological Disease
SB 271046 Hydrochloride (SB 271046A) is a potent, selective, orally active and BBB-permeable **5-HT6 receptor antagonist with pK_i** of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC₅₀=0.16 μM) .

HY-109118A

Masupirdine mesylate SUVN-502 mesylate	5-HT Receptor	Neurological Disease
Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally active, and brain-penetrating *5-HT₆* receptor antagonist (K_i of 2.04 nM for human 5-HT₆ receptor). Masupirdine mesylate has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B)-induced and aging-related memory deficits. Masupirdine mesylate can be used in the research of Alzheimer's disease .

HY-103141

SB-258585 hydrochloride	5-HT Receptor	Neurological Disease
SB-258585 is a high affinity ligand for the 5-HT₆ receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT₆ receptors. SB-258585 can be used to label recombinant and natural 5-HT₆ receptor .

HY-105896

SB399885 1 Publications Verification	5-HT Receptor	Neurological Disease
SB399885 is a potent, selective, brain penetrant and orally active **5-HT6 receptor antagonist with pK_i** values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties .

HY-103110

ST1936 1 Publications Verification	5-HT Receptor Adrenergic Receptor	Neurological Disease
ST1936 is a selective, nanomolar affinity **5-HT₆ receptor agonist with K_i** values of 13 nM, 168 nM and 245 nM for human *5-HT₆, 5-HT₇ and 5-HT_2B receptors, respectively. ST1936 also shows moderate affinity (K_i of 300 nM) for human* and rat α2 adrenergic receptor .

HY-103133

WAY208466 dihydrochloride	5-HT Receptor	Neurological Disease
WAY 208466 dihydrochloride is a potent and selective **5-HT₆ receptor agonist (EC₅₀*=7.3 nM for the human* 5-HT₆ receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex . WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects .

HY-W128798

Sulfabenz	5-HT Receptor	Neurological Disease
Sulfabenz (Compound 9) is an amine-substituted N1-phenylsulfonyl indole derivative. Sulfabenz has binding activity to human 5-HT6 serotonin receptor (K_i: 200 nM). Sulfabenz can be used to study the ligand binding mechanism of 5-HT6 receptor and 5-HT6 receptor-related neurological diseases .

HY-109118

Masupirdine free base SUVN-502 free base	5-HT Receptor	Neurological Disease
Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating *5-HT₆* receptor antagonist (K_i of 2.04 nM for human 5-HT₆ receptor). Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B)-induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease .

HY-120464

PF-05212377 SAM-760	5-HT Receptor	Neurological Disease
PF-05212377 (SAM-760) is an inhibitor for serotonin receptor 5-HT6. PF-05212377 is a substrate for P-gp/non-BCRP human transporter. PF-05212377 exhibits blood brain barrier permeability in non-human primates. PF-05212377 can be used for Alzheimer’s Disease research .

HY-120239

Ro 63-0563	5-HT Receptor	Neurological Disease
Ro 63-0563 is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values of 7.83 and 7.91 for rat and human *5-HT₆* receptors, respectively. Ro 63-0563 has no affinity for other receptors .

HY-14335

Ro 04-6790	5-HT Receptor	Neurological Disease
Ro 04-6790 is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors .

HY-14335A

Ro 04-6790 dihydrochloride	5-HT Receptor	Neurological Disease
Ro 04-6790 dihydrochloride is a potent, competitive and selective *5-HT₆* receptor antagonist with pK_i values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 dihydrochloride has no affinity at other receptors .

HY-103110A

ST1936 oxalate	5-HT Receptor Adrenergic Receptor	Neurological Disease
ST1936 oxalate is a selective, nanomolar affinity **5-HT₆ receptor agonist with K_i** values of 13 nM, 168 nM and 245 nM for human *5-HT₆, 5-HT₇ and 5-HT_2B receptors, respectively. ST1936 oxalate also shows moderate affinity (K_i of 300 nM) for human* and rat α2 adrenergic receptor .

HY-21995

BGC20-761	5-HT Receptor Dopamine Receptor	Neurological Disease
BGC20-761 is a selecvtive *5-HT6* and dopamine receptor antagonist (human receptor K_i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent .

HY-14336AR

SB 271046 Hydrochloride (Standard) SB 271046A (Standard)	5-HT Receptor Reference Standards	Neurological Disease
SB 271046 (Hydrochloride) (Standard) is the analytical standard of SB 271046 (Hydrochloride). This product is intended for research and analytical applications. SB 271046 Hydrochloride (SB 271046A) is a potent, selective, orally active and BBB-permeable 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM) .

HY-14341

E-6837	5-HT Receptor	Metabolic Disease
E-6837 is a selective and orally active *5-HT₆* receptor ligand. E-6837 demonstrates partial agonism at a presumably silent rat 5-HT₆ receptor and full agonism at a constitutively active human 5-HT₆ receptor by monitoring the cAMP signaling pathway. E-6837 induces hypophagia, reduces fat mass and body weight, and improves glycemic control. E-6837 can be used for the research of obesity .

HY-105896R

SB399885 (Standard)	Reference Standards 5-HT Receptor	Neurological Disease
SB399885 (Standard) is the analytical standard of SB399885 (HY-105896). This product is intended for research and analytical applications. SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pK_i values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties .

HY-103110R

ST1936 (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor	Neurological Disease
ST1936 (Standard) is the analytical standard of ST1936 (HY-103110). This product is intended for research and analytical applications. ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with K_i values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor .

HY-W130288

1-(1-Naphthyl)piperazine	5-HT Receptor Adenylate Cyclase Apoptosis Reactive Oxygen Species (ROS)	Cancer
1-(1-Naphthyl)piperazine is a 5-HT receptor modulator that acts as both a 5-HT2A receptor antagonist and 5-HT1A receptor agonist, and binds to human *5-HT6* receptor with a K_i of 120 nM. 1-(1-Naphthyl)piperazine partially inhibits forskolin-stimulated adenylate cyclase activity in calf substantia nigra. 1-(1-Naphthyl)piperazine inhibits UV-induced immunosuppression. 1-(1-Naphthyl)piperazine induces S-phase cell cycle delay, apoptosis and increases ROS levels, leading to inhibit MNT-1 cell proliferation. 1-(1-Naphthyl)piperazine can be used for melanoma research .

HY-123480A

EGIS-7625 free base	5-HT Receptor	Neurological Disease
EGIS-7625 free base is an orally active and selective competitive antagonist of 5-HT2B receptor, with a human K_i value of 1 nM. EGIS-7625 free base shows low affinity for 5-HT2A and 5-HT2C receptors. The pK_i values of EGIS-7625 free base for human 5-HT2B, 5-HT2A and 5-HT2C are 9.0, 6.2 and 7.7, respectively. EGIS-7625 free base alleviates mCPP-induced hypoactivity .

HY-121675A

2-Bromo-LSD D-Tartrate BOL-148 D-Tartrate; Bromolysergide D-Tartrate	5-HT Receptor G protein-coupled Bile Acid Receptor 1	Neurological Disease
2-Bromo-LSD D-Tartrate (BOL-148 D-Tartrate) is a blood-brain barrier-permeable 5-HT_2A partial agonist and competitive partial antagonist. 2-Bromo-LSD D-Tartrate acts as both a potent partial agonist (with an EC₅₀ of 0.81 nM for Gq dissociation) and a potent partial antagonist (with a K_B of 0.18 nM for Gq dissociation) at the 5-HT_2A receptor. 2-Bromo-LSD D-Tartrate exhibits partial agonist activity at multiple aminergic GPCRs, including 5-HT_2A. 2-Bromo-LSD D-Tartrate lacks 5-HT_2B agonist activity. 2-Bromo-LSD D-Tartrate induces dendritogenesis and spinogenesis. 2-Bromo-LSD D-Tartrate reverses the behavioral effects of chronic stress and increases active coping behaviors in mice .

HY-182285A

FOXM1-IN-4 hydrochloride	5-HT Receptor DNA/RNA Synthesis	Cancer
FOXM1-IN-4 hydrochloride is a selective 5-HT₇ receptor inhibitor with a K_i of 92 nM. FOXM1-IN-4 hydrochloride blocks 5-HT₇ receptor signaling to reduce FOXM1, p-FOXM1, cyclin B1, and cdc25B levels. FOXM1-IN-4 hydrochloride acts as an antiproliferative, clonogenic inhibitor, and cell cycle inhibitor that induces G₂/M arrest, reduces G₀/G₁ population. FOXM1-IN-4 hydrochloride can be used for the research of triple-negative breast cancer .

HY-183805

5-HT6R/FAAH modulator 2	5-HT Receptor FAAH	Neurological Disease
5-HT6R/FAAH modulator 2 is a dual 5-HT6R antagonist and FAAH inhibitor with human 5-HT6R pK_i 7.24, human FAAH pIC₅₀ 5.47, and blood-brain barrier penetration.5-HT6R/FAAH modulator 2 modulates serotonergic signaling, blocks 5-HT6R function, inhibits endocannabinoid degradation via FAAH catalytic activity suppression.5-HT6R/FAAH modulator 2 exhibits neuroprotective effects against mitochondrial dysfunction, amyloid-β, and glutamate-induced toxicity, reverses memory deficits.5-HT6R/FAAH modulator 2 shows reduced cytotoxicity relative to oxygen-containing lead compounds.5-HT6R/FAAH modulator 2 can be used for the research of Alzheimer's disease .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

human 5-HT6 receptors

Inhibitors & Agonists