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Cat. No.: HY-W741145

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Dibenzepine-d₃

Dibenzepine-d₃ is the deuterated-labeled Dibenzepine (HY-12391). Dibenzepine is a blood-brain barrier permeable ligand of the histamine H1 receptor (Histamine H1 Receptor), with a K_i value of 0.02 μM. Dibenzepine exhibits varying degrees of affinity for multiple serotonin receptors and dopamine receptors. Dibenzepine can be used in research related to depression, schizophrenia, dementia, and non-specific agitation.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₈D₃N₃O
Molecular Weight:298.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (293 KB)

Dibenzepine-d₃ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

H₁ Receptor

0.02 μM (Ki)

All Histamine Receptor Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 4498-32-2
Molecular Weight 298.40
Formula C₁₈H₁₈D₃N₃O
SMILES

O=C1N(C2=C(N(C3=C1C=CC=C3)C([2H])([2H])[2H])C=CC=C2)CCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bieszczad B, et al. Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs. Bioorganic & medicinal chemistry letters. 2020 Nov 01;30(21):127493.

[2]. Bieszczad B, et al. Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs. Bioorganic & medicinal chemistry letters. 2020 Nov 01;30(21):127493.

[3]. De Leenheer A, et al. Improved method for determining dibenzepine and its N-demethylated metabolites in human urine. J Pharm Sci. 1973 Jan;62(1):31-6.

[4]. Brochon R, et al. The detection and determination of dibenzepine and its metabolites in autopsy material. Arch Toxikol. 1969;24(4):249-59.

[5]. Christensen H, et al. Dibenzepine and its metabolites in blood, muscle, liver, vitreous body and urine from fatal poisoning. Acta Pharmacol Toxicol (Copenh). 1975 Nov;37(5):393-401.

[6]. Bonnichsen R, et al. Determination of dibenzepine in autopsy material. Z Rechtsmed. 1971;68(5):253-60.

[7]. Schlicht HJ, et al. Gas chromatographic determination of dibenzepine and its basic metabolites in biological material. J Chromatogr. 1978 Dec 11;166(2):599-603.

[8]. Langslet A, et al. Effects of dibenzepine and imipramine on the isolated rat heart. Eur J Pharmacol. 1971 May;14(4):333-9. [Content Brief]

[9]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]

[10]. Jadrić R, et al. Comparison of trazodone, diazepame and dibenzepine influences on rat brain beta-endorphins content. Bosnian journal of basic medical sciences. 2007 Aug;7(3):222-5.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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Biological Activity

Description

IC50 & Target

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

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