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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
human Smoothened receptor
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "human Smoothened receptor" in MCE Product Catalog:
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .
Cat. No.: HY-177291
CAS No.: 256397-11-2
Research Areas:
LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers .
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer .
Cat. No.: HY-18287A
CAS No.: 1359944-60-7
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .
Cat. No.: HY-P703220
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SMO; Seven Transmembrane Helix receptor; Prev. SMOH; Smoothened (Drosophila) Homolog; FZD11; Smoothened Homolog (Drosophila); Smoothened, Seven Transmembrane Spanning receptor; Smoothened Homolog; Smoothened, Frizzled Family receptor; CRJS; Frizzled Famil
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704888
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SMO; Seven Transmembrane Helix receptor; Prev. SMOH; Smoothened (Drosophila) Homolog; FZD11; Smoothened Homolog (Drosophila); Smoothened, Seven Transmembrane Spanning receptor; Smoothened Homolog; Smoothened, Frizzled Family receptor; CRJS; Frizzled Famil
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
