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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
human TRPML1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "human TRPML1" in MCE Product Catalog:
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
Research Areas:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Cat. No.: HY-187969
CAS No.: 2742654-01-7
Target:
Research Areas:
EVP-21 is a selective TRPML3 agonist with an EC50 of 4.3 μM for human TRPML3, and it is selective over TRPML1 and human TRPML2. EVP-21 elicits TRPML3 currents in late endosomes/lysosomes and early endosomes. EVP-21 can be used for research on TRPML3-related mechanisms such as emphysema, hearing loss, and yellow fever virus infection .
Cat. No.: HY-P702374
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCOLN1; Transient Receptor Potential Mucolipin 1; Mucolipin TRP Cation Channel 1; Mucolipin 1; TRPML1; Mucolipidin; ML4; Mucolipin-1; TRPM-L1; MG-2; MSTP080; ML1; MST080; Mucolipidosis Type IV Protein; MLIV; Mucolipidosis Type IV; Transient Receptor Poten
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-P701383
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCOLN1; Transient Receptor Potential Mucolipin 1; Mucolipin TRP Cation Channel 1; Mucolipin 1; TRPML1; Mucolipidin; ML4; Mucolipin-1; TRPM-L1; MG-2; MSTP080; ML1; MST080; Mucolipidosis Type IV Protein; MLIV; Mucolipidosis Type IV; Transient Receptor Poten
Species:
Human
Source:
HEK293
Cat. No.: HY-P86974
Synonyms: MCLN1_human antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MCLN1_human antibody; Mcoln 1 antibody; Mcoln1 antibody; MG 2 antibody; MG-2 antibody; MG2 antibody; ML 4 antibody; ML4 antibody; MLIV antibody; MST080 antibody; MSTP080 antibody; Mucolipidin antibody; Mucolipin 1 antibody; Mucolipin-1 antibody; Mucolipin1 antibody; TRP ML1 antibody; TRPML1 antibody;
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
