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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
108 Results for "
human mast cell
" in MedChemExpress (MCE) Product Catalog:
Products (108)
108 Results for "human mast cell" in MCE Product Catalog:
36
Research Areas:
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .
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MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .
7
7 Cited Publications
Synonyms: C48/80 trihydrochloride
Target:
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Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
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6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
5
5 Cited Publications
Cat. No.: HY-P70781
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel Factor; mast cell Growth Factor; C-Kit Ligand; Stem cell Factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF
4
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Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
4
4 Cited Publications
Synonyms: OC000459 sodium
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Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
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4 Cited Publications
Cat. No.: HY-P70576
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating Factor, Multiple; Interleukin 3; P-cell Stimulating Factor; IL-3; P-cell-Stimulating Factor; Hematopoietic Growth Factor; mast-cell Growth Factor; MCGF; mast cell Growth Factor; Multipotential Colony-Stimulating Factor; MGC79398; I
3
3 Cited Publications
Synonyms: NF 113; SAP 113; Methylmercadone
Research Areas:
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
2
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2
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2
2 Cited Publications
Cat. No.: HY-P5641
CAS No.: 190324-47-1
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1
1 Cited Publications
Cat. No.: HY-P4476
CAS No.: 72682-69-0
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1
1
1 Cited Publications
Cat. No.: HY-172458
CAS No.: 473687-20-6
Research Areas:
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .
1
1 Cited Publications
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Research Areas:
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases .
1
1 Cited Publications
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ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases [1] [2] .
1
1 Cited Publications
Cat. No.: HY-P7040A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating Factor, Multiple; Interleukin 3; P-cell Stimulating Factor; IL-3; P-cell-Stimulating Factor; Hematopoietic Growth Factor; mast-cell Growth Factor; MCGF; mast cell Growth Factor; Multipotential Colony-Stimulating Factor; MGC79398; I
1
1 Cited Publications
Cat. No.: HY-P70765
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating Factor, Multiple; Interleukin 3; P-cell Stimulating Factor; IL-3; P-cell-Stimulating Factor; Hematopoietic Growth Factor; mast-cell Growth Factor; MCGF; mast cell Growth Factor; Multipotential Colony-Stimulating Factor; MGC79398; I
1
1 Cited Publications
Cat. No.: HY-P7046
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL9; Homolog Of Mouse T cell And mast cell Growth Factor 40; Interleukin 9; P40 T-cell And mast cell Growth Factor; IL-9; Interleukin-9; T-cell Growth Factor P40; P40 Cytokine; HP40; Cytokine P40; P40
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
