3 Results for "

human nucleus pulposus cells

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "human nucleus pulposus cells" in MCE Product Catalog:

GSK1995057
GSK1995057
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Cat. No.: HY-P991400

Target:  

TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK

Research Areas:  

Inflammation/Immunology

GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .
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Bisdemethoxycucurmin
Bisdemethoxycucurmin
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Cat. No.: HY-N0007A
CAS No.: 24939-16-0
Synonyms: Curcumin III; Didemethoxycurcumin
Category:  

Zingiber officinale Roscoe Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Zingiberaceae

Target:  

Ferroptosis P-glycoprotein DNA/RNA Synthesis

Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .
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VO-OHPic
VO-OHPic
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Cat. No.: HY-110067
CAS No.: 675848-25-6
Target:  

PTEN Apoptosis Autophagy Ferroptosis Reactive Oxygen Species (ROS) Interleukin Related Akt Keap1-Nrf2

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

VO-OHPic is a reversible, noncompetitive PTEN inhibitor with an human IC50 value of 46 nM. VO-OHPic inhibits PTEN signaling, activates Akt-GSK3β and Nrf-2/HO-1 pathways, induces apoptosis resistance and elevates IL-10 levels. VO-OHPic inhibits autophagy, ferroptosis and oxidative stress. VO-OHPic can be used for the research of acute myocardial infarction, intervertebral disc degeneration, cardiomyopathy and cancer .
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