Search Result

Results for "

hydrogen Peroxide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino acid Transporter (1) AMPK (1) Amyloid-β (3) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (8) Arp2/3 Complex (1) Autophagy (2) Bacterial (6) Biochemical Assay Reagents (13) Caspase (2) Cathepsin (1) Cholinesterase (ChE) (5) CXCR (1) DNA/RNA Synthesis (3) Drug Derivative (4) Drug Intermediate (1) Dynamin (1) Endogenous Metabolite (20) Environmental Pollutants (3) Ferroptosis (2) Fluorescent Dye (27) Fungal (2) GABA Receptor (1) Glutathione Peroxidase (3) Glutathione Reductase (GR) (2) Glycosidase (3) Histone Demethylase (1) HSV (1) IFNAR (1) Interleukin Related (3) IRAK (1) Isotope-Labeled Compounds (4) JAK (1) Keap1-Nrf2 (1) KMO (1) Lipase (1) Liposome (1) MDM-2/p53 (1) Mitochondrial Metabolism (4) MOFs (1) Monoamine Oxidase (7) NADH Dehydrogenase (1) NADPH Oxidase (2) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (2) Parasite (2) PARP (1) PGC-1α (1) PGE synthase (2) Phytohormone (1) PPAR (2) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (31) Reference Standards (10) ROS Kinase (2) Sirtuin (1) SOD (5) STAT (1) TNF Receptor (3) TrxR (1) Tyrosinase (1) α-synuclein (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (8) Endocrinology (3) Infection (7) Inflammation/Immunology (25) Metabolic Disease (43) Neurological Disease (26)
Oligonucleotides:	Cationic Lipids (1) Cholesterol (1)

139

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Na+/H+ Exchanger (NHE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0828

Pterostilbene 5+ Cited Publications	Autophagy	Inflammation/Immunology Cancer
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-P2902

Glucose oxidase 5+ Cited Publications	Endogenous Metabolite	Cancer
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .

HY-B1335

Pentetic acid 3 Publications Verification Diethylenetriaminepentaacetic acid; DTPA	Environmental Pollutants Biochemical Assay Reagents	Others
Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .

HY-W011664

1,3-Diphenylisobenzofuran Maximum Cited Publications 28 Publications Verification DPBF	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals .

HY-134757

Lactate oxidase, Microorganism 2 Publications Verification	Endogenous Metabolite	Others
Lactate oxidase (EC 1.13.12.4) belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate .

HY-D0169

Phenol Red 1 Publications Verification Phenolsulfonephthalein	Environmental Pollutants Fluorescent Dye	Others
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

HY-100111

GLX351322 Maximum Cited Publications 47 Publications Verification	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-129064

Superoxide dismutase, Porcine erythrocytes 2 Publications Verification SOD	SOD	Inflammation/Immunology Cancer
Superoxide dismutase, Porcine erythrocytes (SOD) is the only antioxidant enzyme that scavenges the superoxide anion by converting this free radical to oxygen and hydrogen peroxide, thus preventing peroxynitrite production and further damage. Superoxide dismutase, Porcine erythrocytes is extensively researched and used in anti-inflammatory, antitumor, radiation protection, and antisenility applications .

HY-121026

DMNQ 5+ Cited Publications	Reactive Oxygen Species (ROS) ROS Kinase	Cardiovascular Disease
DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production .

HY-15930

TMB 5+ Cited Publications BM blue; Sure Blue TMB	Fluorescent Dye MOFs Reactive Oxygen Species (ROS)	Others
TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-B1770

Sodium Iodide,99%	Environmental Pollutants Biochemical Assay Reagents	Cardiovascular Disease Endocrinology
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction .

HY-15914

DHBS DCHBS	Fluorescent Dye	Others
DHBS (3, 5-dichloro-2-hydroxybenzenesulfonate) is used in conjunction with 4-aminoantipyrine (4-AAP) (HY-W100990) and hydrogen peroxide (H₂O₂) for chromogenic quantitation of peroxidase in coupled enzymatic reactions. Component of Trinder reagent for use with peroxidase to measure generation of hydrogen peroxide in automated systems .

HY-109110

Avasopasem manganese GC-4419; M-40419	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O₂ ^- to hydrogen* peroxide (H₂O₂), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-P2833

Glutathione Peroxidase GSH-Px; EC 1.11.1.9	Glutathione Peroxidase	Metabolic Disease
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H₂O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .

HY-N0525

Ethyl gallate 2 Publications Verification	Bacterial	Metabolic Disease Cancer
Ethyl gallate is a nonflavonoid phenolic compound and also a scavenger of hydrogen peroxide.

HY-120972

Pentafluorobenzenesulfonyl fluorescein	Fluorescent Dye	Others
Pentafluorobenzenesulfonyl fluorescein is a H₂O₂-selective sensor that can be used to detect H₂O₂ levels in cells. Pentafluorobenzenesulfonyl fluorescein is generally non-fluorescent, but emits fluorescence when its sulfonyl bond undergoes perhydrolysis by H₂O₂ . Pentafluorobenzenesulfonyl fluorescein undergoes slight cleavage of its sulfonate ester bond by [Cu (phen)₂] ²⁺, and can detect hydrogen peroxide around the ablation sites of fin tissues and keratinocytes in zebrafish larvae .

HY-119171

GSK 366	KMO	Neurological Disease Inflammation/Immunology
GSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC₅₀values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMO’s substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H₂O₂) production and reduces H₂O₂ levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimer’s disease .

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dye Glutathione Peroxidase	Others
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-101859

NucPE1 5 Publications Verification Nuc-H2O2 Probe	Reactive Oxygen Species (ROS)	Others
NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-D0945

Xylene Cyanol FF	Fluorescent Dye	Others
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .

HY-D1157

HKPerox-2 5 Publications Verification	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-172942

SP11	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Dynamin	Cardiovascular Disease Infection Neurological Disease Cancer
SP11 is a mitochondrial fission protein 1 (Fis1) inhibitor with an IC₅₀ of 9.4 μM. SP11 binds only to activated Fis1 by engaging Cys41. SP11 preserves mitochondrial integrity and function during oxidative stress, inhibits hydrogen peroxide-induced mitochondrial ROS production, mitochondrial fragmentation, and Drp1 mitochondrial translocation. SP11 can be used for the research of parkinson’s disease .

HY-D0233

Leucocrystal violet	Fluorescent Dye	Others
Leucocrystal violet is a cationic triarylmethane dye. Leucocrystal violet generates a colored purple product in the presence of hydrogen peroxide and horseradish peroxidase, or when oxidized by periodate under the catalysis of horseradish peroxidase. Leucocrystal violet serves as a chromogenic reagent for the determination of submicrogram-level hydrogen peroxide, with no interference from tryptophan, persulfate or chromate. Leucocrystal violet reacts with blood to produce a purple/violet color in the presence of hydrogen peroxide; it forms a very weak fluorophore when acting with whole blood in an unbuffered solution, with a maximum absorption wavelength of 630 nm and a maximum fluorescence emission wavelength of 665 nm upon excitation at 630 nm. Leucocrystal violet is widely used for staining blood residues on porous and non-porous materials .

HY-E70385

Oxalate Oxidase	Endogenous Metabolite	Others
Oxalate Oxidase, or oxalate oxidase, catalyzes the oxidation of oxalic acid to hydrogen peroxide and carbon dioxide in the presence of oxygen. Oxalate Oxidase can be found in a variety of plants (such as barley) and microorganisms and can be used to treat wastewater and filtrates containing oxalic acid .

HY-P2910

Galactose Oxidase, Dactylium dendroides 2 Publications Verification GOase	Endogenous Metabolite	Others
Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide .

HY-P4280

Arg-Tyr H-Arg-Tyr-OH	Reactive Oxygen Species (ROS)	Others
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

HY-105005

Crisdesalazine AAD-2004	Prostaglandin Receptor PGE synthase Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology
Crisdesalazine (AAD-2004) is a microsomal prostaglandin E₂ synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE₂ production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury .

HY-D0830

Calcein (tetraethyl ester) Fluorexon tetraethyl ester	Fluorescent Dye	Others
Calcein tetraethyl ester is a tetraethylated derivative of calcein, with its core function serving as a live cell-specific fluorescent tracer. Calcein tetraethyl ester can diffuse between human periodontal ligament cells via gap junctions, thus enabling the evaluation of gap junction intercellular communication function, and its diffusion is enhanced under hydrogen peroxide induction. Calcein tetraethyl ester can be applied in the fields of cell biology and fluorescent labeling .

HY-135849C

Catalase, trichoderma reesei	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Catalase, trichoderma reesei is a catalase derived from Trichoderma reesei. Catalase, trichoderma reesei dismutates hydrogen peroxide into oxygen and water, helping cells resist oxidative damage caused by hydrogen peroxide .

HY-126474

MitoB bromide	Reactive Oxygen Species (ROS)	Inflammation/Immunology
MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .

HY-E70074

Monoamine oxidase, plasma	Monoamine Oxidase	Neurological Disease
Monoamine oxidase (EC 1.4.3.4) is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions .

HY-N0828R

Pterostilbene (Standard)	Reference Standards Autophagy	Inflammation/Immunology Cancer
Pterostilbene (Standard) is the analytical standard of Pterostilbene. This product is intended for research and analytical applications. Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-W100959

Duroquinone Tetramethylquinone	Drug Derivative	Others
Duroquinone (Tetramethylquinone) is a model compound of amphiphilic quinone, which can be used as an oxidative-reductive activity probe. Duroquinone can be easily reduced by biological systems to hydrogen peroxide (DQH₂) or semi-quinone free radicals (DQ•⁻). Duroquinone can freely pass through the cell membrane, facilitating the study of the electron transfer process inside and outside the cells. Duroquinone can be used to investigate the relationship between metabolism in the pulmonary circulation and endothelial cells .

HY-W037819

6-Methylpterin	Drug Derivative	Metabolic Disease
6-Methylpterin is a derivative of the essential B vitamin Folic acid (HY-16637). 6-Methylpterin generates singlet oxygen and hydrogen peroxide when exposed to Photoirradiation. 6-Methylpterin can be used for the detection of pterins in urine .

HY-W415108

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate	Fluorescent Dye	Others
10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .

HY-W927359

Fluorescein hydrazide (3,6-Dihydroxyxanthane)	Fluorescent Dye	Others
Fluorescein hydrazide (3,6-Dihydroxyxanthane) is a fluorescein dye that can be used for the fluorophotometric determination of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) .

HY-132829

Rucosopasem manganese GC4711	Reactive Oxygen Species (ROS)	Cancer
Rucosopasem manganese (GC4711) is a selective superoxide dismutase mimetic that converts superoxide to hydrogen peroxide. Rucosopasem manganese can be used for the research of cancer .

HY-149234

MAO-B-IN-18	Monoamine Oxidase	Neurological Disease
MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC₅₀s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures .

HY-132183

Chloride peroxidase	Endogenous Metabolite	Metabolic Disease
Chloride peroxidase is a monomeric, heme-containing enzyme. Chloride peroxidase is capable of electrophilic chlorinations through the umpolung of chloride by oxidation with hydrogen peroxide .

HY-139182

MAGL-IN-3	Endogenous Metabolite	Metabolic Disease
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC₅₀=34.1 nM). It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

HY-103385

NCX4040 NO-Aspirin	Apoptosis	Inflammation/Immunology Cancer
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects .

HY-113045

Aquacobalamin	Endogenous Metabolite	Metabolic Disease
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO₅ ^- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .

HY-P2742B

Ascorbate oxidase, acremonium sp	Endogenous Metabolite	Metabolic Disease
Ascorbate oxidase, acremonium sp is a member of the multicopper blue oxidase family and primarily exists in plants as a free enzyme in the cytoplasm or bound to the cell wall. Ascorbate oxidase, acremonium sp has a high activity in catalyzing the oxidation of ascorbic acid to dehydroascorbic acid, regulating various cellular processes related to plant growth, protection, and development. Ascorbate oxidase, acremonium sp can be used to detect hydrogen peroxide .

HY-P10400A

AtPep1 TFA	Phytohormone	Infection
AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection .

HY-N8453

Macranthoin G Methyl 3,5-dicaffeoyl quinic acid	p38 MAPK	Neurological Disease
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease .

HY-132178

Cytochrome P450	Endogenous Metabolite	Metabolic Disease Cancer
Cytochrome P450 is a family of monooxygenase enzymes that catalyzes the conversion of fatty acids to terminal alkenes using hydrogen peroxide as a cosubstrate. Cytochrome P450 as membrane-bound hemoproteins, plays important roles in the detoxification of drugs, cellular metabolism, and homeostasis .

HY-N0464S

Quinic acid-13C3	Isotope-Labeled Compounds Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-P2888A

Bilirubin oxidase, bacillus cereus BOD, bacillus cereus	Endogenous Metabolite	Metabolic Disease
Bilirubin oxidase, bacillus cereus is a multi-copper oxidase that catalyzes the oxidation of bilirubin into biliverdin, as well as other tetrapyrroles, phenols, and aryl diamines. Bilirubin oxidase, bacillus cereus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, bacillus cereus can be used to develop enzyme-based biosensors .

HY-P2888C

Bilirubin oxidase, Bacillus pumilus BOD, Bacillus pumilus	Endogenous Metabolite	Metabolic Disease
Bilirubin oxidase (BOD), Bacillus pumilus is a multicopper oxidase that catalyzes the oxidation of bilirubin to biliverdin, as well as other tetrapyrrole, phenols, and aryl diamines. Bilirubin oxidase, Bacillus pumilus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, Bacillus pumilus can be used to develop enzyme-based biosensors .

Cat. No.	Product Name	Type

HY-W011664

1,3-Diphenylisobenzofuran

Maximum Cited Publications

28 Publications Verification

DPBF

Fluorescent Dyes

1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals .

HY-D0169

Phenol Red 1 Publications Verification Phenolsulfonephthalein	Fluorescent Dyes
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

HY-15930

TMB

5+ Cited Publications

BM blue; Sure Blue TMB

Fluorescent Dyes

TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-15914

DHBS DCHBS	Fluorescent Dyes
DHBS (3, 5-dichloro-2-hydroxybenzenesulfonate) is used in conjunction with 4-aminoantipyrine (4-AAP) (HY-W100990) and hydrogen peroxide (H₂O₂) for chromogenic quantitation of peroxidase in coupled enzymatic reactions. Component of Trinder reagent for use with peroxidase to measure generation of hydrogen peroxide in automated systems .

HY-15930A

TMB dihydrochloride

5+ Cited Publications

BM blue dihydrochloride; Sure Blue TMB dihydrochloride

Fluorescent Dyes

TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dyes
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-101859

NucPE1 5 Publications Verification Nuc-H2O2 Probe	Fluorescent Dyes
NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-D0945

Xylene Cyanol FF

Fluorescent Dyes

Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .

HY-D1157

HKPerox-2 5 Publications Verification	Fluorescent Dyes
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-D0233

Leucocrystal violet

Fluorescent Dyes

Leucocrystal violet is a cationic triarylmethane dye. Leucocrystal violet generates a colored purple product in the presence of hydrogen peroxide and horseradish peroxidase, or when oxidized by periodate under the catalysis of horseradish peroxidase. Leucocrystal violet serves as a chromogenic reagent for the determination of submicrogram-level hydrogen peroxide, with no interference from tryptophan, persulfate or chromate. Leucocrystal violet reacts with blood to produce a purple/violet color in the presence of hydrogen peroxide; it forms a very weak fluorophore when acting with whole blood in an unbuffered solution, with a maximum absorption wavelength of 630 nm and a maximum fluorescence emission wavelength of 665 nm upon excitation at 630 nm. Leucocrystal violet is widely used for staining blood residues on porous and non-porous materials .

HY-D0830

Calcein (tetraethyl ester)

Fluorexon tetraethyl ester

Fluorescent Dyes

Calcein tetraethyl ester is a tetraethylated derivative of calcein, with its core function serving as a live cell-specific fluorescent tracer. Calcein tetraethyl ester can diffuse between human periodontal ligament cells via gap junctions, thus enabling the evaluation of gap junction intercellular communication function, and its diffusion is enhanced under hydrogen peroxide induction. Calcein tetraethyl ester can be applied in the fields of cell biology and fluorescent labeling .

HY-W415108

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate

Fluorescent Dyes

10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .

HY-15930C

TMB monosulfate

5+ Cited Publications

BM blue monosulfate; Sure Blue TMB monosulfate

Fluorescent Dyes

TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-W927359

Fluorescein hydrazide (3,6-Dihydroxyxanthane)	Fluorescent Dyes
Fluorescein hydrazide (3,6-Dihydroxyxanthane) is a fluorescein dye that can be used for the fluorophotometric determination of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) .

HY-DY1053

1,3-Diphenylisobenzofuran (solution)

Fluorescent Dyes

1,3-Diphenylisobenzofuran (DPBF) (solution) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals .
Solvent and concentration: DMSO: 10 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-15930R

TMB (Standard)

BM blue (Standard); Sure Blue TMB (Standard)

Fluorescent Dyes

TMB (Standard) is the analytical standard of TMB. This product is intended for research and analytical applications. TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-D3000

NIR-RED ROS-H2O2 Probe

Fluorescent Dyes

NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI) .

HY-W402148

10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate	Fluorescent Dyes
10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate, a phenyl ester of acridinium esters, is a fluorescent dye that produces chemiluminescent under neutral conditions. 10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate can be used for the measurement of hydrogen peroxide .

HY-D0391

C.I Acid orange 8	Fluorescent Dyes
C.I Acid orange 8 is an acidic orange dye that photochemically decolorizes during a UV/hydrogen peroxide process.

HY-D0233R

Leucocrystal violet (Standard)

Fluorescent Dyes

Leucocrystal violet (Standard) is the analytical standard of Leucocrystal violet (HY-D0233). This product is intended for research and analytical applications. Leucocrystal violet is a cationic triarylmethane dye. Leucocrystal violet generates a colored purple product in the presence of hydrogen peroxide and horseradish peroxidase, or when oxidized by periodate under the catalysis of horseradish peroxidase. Leucocrystal violet serves as a chromogenic reagent for the determination of submicrogram-level hydrogen peroxide, with no interference from tryptophan, persulfate or chromate. Leucocrystal violet reacts with blood to produce a purple/violet color in the presence of hydrogen peroxide; it forms a very weak fluorophore when acting with whole blood in an unbuffered solution, with a maximum absorption wavelength of 630 nm and a maximum fluorescence emission wavelength of 665 nm upon excitation at 630 nm. Leucocrystal violet is widely used for staining blood residues on porous and non-porous materials.

HY-D3139

Pinkment-OAc	Fluorescent Dyes
Pinkment-OAc is an AND logic gate-based dual-analyte-dependent fluorescence inducer (Ex/Em = 545 nm/590 nm) that can be used for the simultaneous detection of hydrogen peroxide (H₂O₂) and esterases (e.g., porcine liver esterase PLE). Pinkment-OAc triggers a fluorescent response only when both esterase and hydrogen peroxide are present .

HY-D3168

PCL-2

Fluorescent Dyes

PCL-2 is a reactive oxygen species-responsive fluorescent probe that shows almost no response to biologically relevant reactive oxygen species other than hydrogen peroxide. PCL-2 reacts with hydrogen peroxide to release 6-hydroxy-2-cyanobenzothiazole. PCL-2 can be used for chemoselective imaging of hydrogen peroxide in in vitro models and acute inflammation mouse models. PCL-2 is applicable to studies related to acute inflammation .

HY-D3140

MB-m-borate

Fluorescent Dyes

MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research .

HY-D3141

DR probe

Fluorescent Dyes

DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

HY-101859R

NucPE1 (Standard) Nuc-H2O2 Probe (Standard)	Fluorescent Dyes
NucPE1 (Standard) (Nuc-H2O2 Probe (Standard)) is the analytical standard of NucPE1 (HY-101859). This product is intended for research and analytical applications. NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-D3143

QM-B-CF	Fluorescent Dyes
QM-B-CF is a sequential dual-lock chemiluminescent/fluorescent dual-mode probe designed for the specific detection of H₂O₂, and it can produce enhanced chemiluminescence upon photoirradiation. QM-B-CF generates chemiluminescent signals only under the conditions of H₂O₂ and light exposure in vitro, in cancer cells, and in tumor-bearing nude mice (Ex/Em = 514 nm/600 nm) .

Cat. No.	Product Name	Type

HY-B1770

Sodium Iodide,99%	Biochemical Assay Reagents
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction .

HY-D0945

Xylene Cyanol FF

Biochemical Assay Reagents

HY-W127558

Cholesterol-PEG 600	Biochemical Assay Reagents
Cholesterol-PEG 600 is a synthetic cholesterol derivative and also a Aβ (1-42) binder. Cholesterol-PEG 600 promotes the fibrillogenesis of Aβ (1-42). Cholesterol-PEG 600 is applicable to the research of Alzheimer's disease .

HY-NP199

Bovine pituitary extract 1 Publications Verification	Biochemical Assay Reagents
Bovine pituitary extract is a bovine pituitary extract that can be used as a mitogenic supplement in serum-free growth media. Bovine pituitary extract is rich in growth factors. Bovine pituitary extract not only promotes the proliferation of corneal keratinocytes and maintains their phenotype, but also exerts significant antioxidant stress protective effects on human prostate epithelial cells .

HY-W423191

Maltobionic acid

4-O-α-D-Glucopyranosyl-D-gluconic acid

Biochemical Assay Reagents

Maltobionic acid (4-O-α-D-Glucopyranosyl-D-gluconic acid) is an orally active oligosaccharide and iron chelator with antibacterial activity. Maltobionic acid inhibits the expression of NFATc1, suppresses osteoclast differentiation, inhibits bone resorption, and increases serum calcitonin levels. Maltobionic acid protects mammalian cells from hydrogen peroxide (H₂O₂)-induced oxidative damage; resists fermentation by the gut microbiota; and exhibits anti-digestive and anti-fermentative properties. Maltobionic acid can be used in research related to osteoporosis, bacterial infections, and constipation .

HY-15930B

TMB dihydrochloride x.hydrate

5+ Cited Publications

Sure Blue TMB dihydrochloride x.hydrate

Biochemical Assay Reagents

TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

Cat. No.	Product Name	Target	Research Area

HY-P4280

Arg-Tyr H-Arg-Tyr-OH	Reactive Oxygen Species (ROS)	Others
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

HY-P4846

Ac-Pro-Gly-Pro-OH 2 Publications Verification	CXCR Apoptosis IFNAR TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of TNF-α and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .

HY-P1997

Ferrichrome Iron-free Desferrichrome; DFC; N-Desferriferrichrome	Biochemical Assay Reagents	Others
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

HY-P10400A

AtPep1 TFA	Phytohormone	Infection
AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection .

HY-P11638

Mitochondrial-targeted peptide BP29	Mitochondrial Metabolism	Neurological Disease Inflammation/Immunology
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia .

HY-P11638A

Mitochondrial-targeted peptide BP29 acetate	Mitochondrial Metabolism	Neurological Disease Inflammation/Immunology
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1645

Papain Maximum Cited Publications 15 Publications Verification	Carica papaya L. Structural Classification Natural Products Classification of Application Fields Caricaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cathepsin
Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .

HY-N0828

Pterostilbene 5+ Cited Publications	Monophenols other families Stilbenes Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Infection Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N0525

Ethyl gallate 2 Publications Verification	Paeonia lactiflora Pall. Classification of Application Fields Phenols Polyphenols Plants Paeoniaceae Disease Research Fields Source Classification Cancer	Bacterial
Ethyl gallate is a nonflavonoid phenolic compound and also a scavenger of hydrogen peroxide.

HY-N10455

24-Epicastasterone 2 Publications Verification 24-epi-Castasterone	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Brassinolide Phytohormone Disease Research Fields Source Classification Agricultural Research	Drug Derivative
24-Epicastasterone (24-epi-Castasterone) is a bioactive brassinosteroid and a ligand of ABCB1 and ABCB19 in Arabidopsis thaliana. 24-Epicastasterone stimulates the ATPase activity of ABCB19 and the ATP hydrolysis activity of ABCB1, which drive the efflux of substances from plant cells. 24-Epicastasterone increases the activities of catalase and guaiacol peroxidase in the roots of wheat seedlings. 24-Epicastasterone alleviates heat-induced lipid peroxidation through a ROS-dependent mechanism and enhances the heat tolerance of common wheat seedlings .

HY-Y1366

Hydroxyacetone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Arp2/3 Complex Apoptosis
Hydroxyacetone is a toxic compound. Hydroxyacetone can be isolated from e-cigarette aerosols. Hydroxyacetone reduces the activity of cellular Mitochondrial reductase (with an IC₅₀ of 5.53 mg/mL for mitochondrial reductase in BEAS-2B cells) and increases ROS levels. Hydroxyacetone induces mitochondrial stress and oxidative damage. Hydroxyacetone induces destabilization of F-actin. At high concentrations, Hydroxyacetone promotes cell rounding and Apoptotic body formation. Hydroxyacetone exerts toxic effects on cells including airway epithelial cells and possesses respiratory toxicity potential .\n

HY-N10423

Cubebin (-)-Cubebin	Structural Classification Classification of Application Fields Lignans Piperaceae Piper cubeba L.f. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK
Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .

HY-N0828R

Pterostilbene (Standard)	Structural Classification Monophenols other families Stilbenes Phenols Plants Source Classification	Reference Standards Autophagy
Pterostilbene (Standard) is the analytical standard of Pterostilbene. This product is intended for research and analytical applications. Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-106784A

(E)-Ajoene	Natural Products Allium sativum L. Plants Amaryllidaceae Source Classification	Fungal Apoptosis
(E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region .

HY-N3027

Soyasaponin Aa 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	PPAR Reactive Oxygen Species (ROS)
Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity .

HY-132183

Chloride peroxidase	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Chloride peroxidase is a monomeric, heme-containing enzyme. Chloride peroxidase is capable of electrophilic chlorinations through the umpolung of chloride by oxidation with hydrogen peroxide .

HY-113045

Aquacobalamin	Microorganisms Source Classification	Endogenous Metabolite
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO₅ ^- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .

HY-N8453

Macranthoin G Methyl 3,5-dicaffeoyl quinic acid	Caprifoliaceae Lonicera japonica Thunb. Phenols Polyphenols Plants Source Classification	p38 MAPK
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease .

HY-132178

Cytochrome P450	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Cytochrome P450 is a family of monooxygenase enzymes that catalyzes the conversion of fatty acids to terminal alkenes using hydrogen peroxide as a cosubstrate. Cytochrome P450 as membrane-bound hemoproteins, plays important roles in the detoxification of drugs, cellular metabolism, and homeostasis .

HY-N3563

Celaphanol A	Terpenoids Celastraceae Diterpenoids Celastrus Plants Celastrus orbiculatus Thunb. Source Classification	Others
Celaphanol A is a diterpene that can be isolated from the root bark of Celastrus orbiculatus. Celaphanol A shows neuroprotective effect against a hydrogen peroxide-induced cytotoxicity in PC12 cells .

HY-N0525R

Ethyl gallate (Standard)	Structural Classification Paeonia lactiflora Pall. Phenols Polyphenols Plants Paeoniaceae Source Classification	Reference Standards Bacterial
Ethyl gallate (Standard) is the analytical standard of Ethyl gallate. This product is intended for research and analytical applications. Ethyl gallate is a nonflavonoid phenolic compound and also a scavenger of hydrogen peroxide.

HY-N8713

4-Methyl-6-phenyl-2H-pyranone	Natural Products Classification of Application Fields Other Diseases Nelumbo nucifera Gaertn. Plants Nymphaeaceae Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
4-Methyl-6-phenyl-2H-pyranone can be used for the synthesis of N-hydroxypyridone derivatives, which can protect astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality .

HY-N2687

5-n-Tricosylresorcinol	Microorganisms Classification of Application Fields Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	DNA/RNA Synthesis
5-n-Tricosylresorcinolthe is the first cyst lipid. 5-n-Tricosylresorcinolthe has metahydroxyl group which allows it to self-associate forming a staggered-chain conformation in which the polar head groups have heaxagonal symmetry. 5-n-Tricosylresorcinolthe reduces hydrogen peroxide-induced DNA damage .

HY-N0464R

D-(-)-Quinic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N3027R

Soyasaponin Aa (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Plants Source Classification	Reference Standards PPAR Reactive Oxygen Species (ROS)
Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa (HY-N3027). Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity .

HY-N15727

2,5-Dimethylchromone-7-O-β-D-glucopyranoside	Rheum australe D. Don Polygonaceae Plants Saccharides Monosaccharides Source Classification	Others
2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .

HY-N17872

Tenuifoliose W	Structural Classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd. Source Classification	Drug Derivative
Tenuifoliose W is a sugar ester found in the roots of Polygala tenuifolia Willd. Tenuifoliose W targets hydrogen peroxide-induced oxidative stress in keratinocytes. Tenuifoliose W can be used for the research of skin aging .

HY-N11721

5-Hydroxyaloin A	Structural Classification Liliaceae Aloe microstigma Salm-Dyck Phenols Polyphenols Plants Source Classification	SOD Lipase
5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity .

HY-W019724R

2,2-Dihydroxyacetic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Drug Intermediate Reactive Oxygen Species (ROS)
2,2-Dihydroxyacetic acid (Standard) is the analytical standard of 2,2-Dihydroxyacetic acid (HY-W019724). This product is intended for research and analytical applications. 2,2-Dihydroxyacetic acid is a key intermediate used in the synthesis of 3-aminocoumarone derivatives, which exhibit significant activity in chemiluminescence reactions and can be used for detecting hydrogen peroxide and evaluating urease activity .

Cat. No.	Product Name	Chemical Structure

HY-N0464S

Quinic acid-13C3
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-126474S

MitoB-d15 bromide
MitoB-d₁₅ (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .

HY-D0233S

Leucocrystal violet-d6

Leucocrystal violet-d₆ is the deuterium labeled Leucocrystal violet (HY-D0233). Leucocrystal violet is a cationic triarylmethane dye. Leucocrystal violet generates a colored purple product in the presence of hydrogen peroxide and horseradish peroxidase, or when oxidized by periodate under the catalysis of horseradish peroxidase. Leucocrystal violet serves as a chromogenic reagent for the determination of submicrogram-level hydrogen peroxide, with no interference from tryptophan, persulfate or chromate. Leucocrystal violet reacts with blood to produce a purple/violet color in the presence of hydrogen peroxide; it forms a very weak fluorophore when acting with whole blood in an unbuffered solution, with a maximum absorption wavelength of 630 nm and a maximum fluorescence emission wavelength of 665 nm upon excitation at 630 nm. Leucocrystal violet is widely used for staining blood residues on porous and non-porous materials.

HY-W749825

Pentetic acid-13C5

Pentetic acid- ¹³C₅ (Diethylenetriaminepentaacetic acid- ¹³C₅) is the ¹³C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .

Cat. No.	Product Name		Classification

HY-W127558

Cholesterol-PEG 600		Cholesterol
Cholesterol-PEG 600 is a synthetic cholesterol derivative and also a Aβ (1-42) binder. Cholesterol-PEG 600 promotes the fibrillogenesis of Aβ (1-42). Cholesterol-PEG 600 is applicable to the research of Alzheimer's disease .

HY-159861

Ionizable Lipid 4		Cationic Lipids
Ionizable Lipid 4 is an ionizable cationic lipid and a rearrangement product of the cationic lipid CA-lipid 5 induced by hydrogen peroxide .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

hydrogen Peroxide

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products