64 Results for "

immunosuppressive agent

" in MedChemExpress (MCE) Product Catalog:
Products (64)

64 Results for "immunosuppressive agent" in MCE Product Catalog:

78
78 Publications Verification
Cat. No.: HY-17420A
CAS No.: 6055-19-2
Synonyms: Cyclophosphamide monohydrate
Research Areas:  

Cancer

Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
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73
73 Cited Publications
Cat. No.: HY-16569
CAS No.: 64-86-8
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
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20
20 Cited Publications
Cat. No.: HY-B0245
CAS No.: 55-98-1
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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20
20 Cited Publications
Cat. No.: HY-B0214
CAS No.: 53-03-2
Synonyms: Dehydrocortisone
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .
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18
18 Cited Publications
Cat. No.: HY-13677
CAS No.: 50-44-2
Purity:  99.93%
Synonyms: Mercaptopurine; 6-MP
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.
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18
18 Cited Publications
Cat. No.: HY-13677A
CAS No.: 6112-76-1
Purity:  99.74%
Synonyms: Mercaptopurine hydrate; 6-MP hydrate
Research Areas:  

Cancer

6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
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14
14 Cited Publications
Cat. No.: HY-B0421
CAS No.: 24280-93-1
Synonyms: Mycophenolate
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .
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14
14 Cited Publications
Cat. No.: HY-B0421A
CAS No.: 37415-62-6
Synonyms: Mycophenolate sodium
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .
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8
8 Cited Publications
Cat. No.: HY-B0256
CAS No.: 446-86-6
Synonyms: BW 57-322
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .
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3
3 Cited Publications
Cat. No.: HY-100711A
CAS No.: 56144-17-3
Purity:  98.00%
Synonyms: Prodigiosine hydrochloride
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
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2
2 Cited Publications
Cat. No.: HY-148432
CAS No.: 113143-13-8
Purity:  98.07%
Target:  

HIV

Research Areas:  

Inflammation/Immunology

FGF22-IN-1 (compound c1) is a potent CD4 D1 inhibitor. FGF22-IN-1 can be used as immunosuppressive agent .
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1
1 Cited Publications
Cat. No.: HY-B0421S
CAS No.: 1185242-90-3
Synonyms: Mycophenolate-d3
Mycophenolic acid-d3 (Mycophenolate-d3) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
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1
1 Cited Publications
Cat. No.: HY-112613
CAS No.: 1616413-96-7
Purity:  99.59%
Target:  

PI4K

Research Areas:  

Inflammation/Immunology

UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent .
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1
1 Cited Publications
Cat. No.: HY-N7700A
Synonyms: G2013 sodium
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes SHIP1 and SOCS1, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases .
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Cat. No.: HY-P99728
CAS No.: 2056881-92-4
Synonyms: RG7835; RO7049665
Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis .
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Cat. No.: HY-P99325
CAS No.: 252662-47-8
Synonyms: IDEC-131; Anti-Human CD40 ligand Recombinant Antibody

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease .
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Cat. No.: HY-B0245S
CAS No.: 116653-28-2
Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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Cat. No.: HY-101603
CAS No.: 202057-76-9
Purity:  99.75%
Synonyms: FK778
Research Areas:  

Inflammation/Immunology

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent. Manitimus is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No.: HY-B0245R
CAS No.: 55-98-1
Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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Cat. No.: HY-101813
CAS No.: 147076-36-6
Purity:  99.76%
Synonyms: HR325
Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 µM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor .
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