446-86-6
446-86-6
Chemical Structure
Azathioprine
Synonym(s): BW 57-322
- CAS No.: 446-86-6
- Formula:C9H7N7O2S
- Molecular Weight:277.26
IUPAC Name: 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-7H-purine
InChIKey: LMEKQMALGUDUQG-UHFFFAOYSA-N
SMILES: O=[N+](C1=C(SC2=C3NC=NC3=NC=N2)N(C)C=N1)[O-]
Biological Activity: Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][3].
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Azathioprine | 99.99% | Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | ||||||||||||||||||||
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Azathioprine (Standard) | 99.82% | Azathioprine (Standard) is the analytical standard of Azathioprine. This product is intended for research and analytical applications. Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | ||||||||||||||||||||
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Azathioprine-13C4 | Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | |||||||||||||||||||||
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Azathioprine-d3 | Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | |||||||||||||||||||||
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References
- [1]. Patel, A.A., R.A. Swerlick, and C.O. McCall, Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol, 2006. 55(3): p. 369-89. [Content Brief]
- [3]. Dubinsky, M.C., Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol, 2004. 2(9): p. 731-43. [Content Brief]
