446-86-6
446-86-6
Chemical Structure
Azathioprine
Synonym(s): BW 57-322
- No. CAS: 446-86-6
- Formula:C9H7N7O2S
- Molecular Weight:277.26
IUPAC Name: 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-7H-purine
InChIKey: LMEKQMALGUDUQG-UHFFFAOYSA-N
SMILES: O=[N+](C1=C(SC2=C3NC=NC3=NC=N2)N(C)C=N1)[O-]
Biological Activity: Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Azathioprine | 99.99% | Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | ||||||||||||||||||||
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Azathioprine (Standard) | 99.82% | Azathioprine (Standard) is the analytical standard of Azathioprine. This product is intended for research and analytical applications. Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | ||||||||||||||||||||
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Azathioprine-13C4 | Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | |||||||||||||||||||||
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Azathioprine-d3 | Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | |||||||||||||||||||||
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MNITMT | 99.79% | MNITMT is a more potent immunosuppressive agent without bone marrow toxicity. | ||||||||||||||||||||
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Thiamiprine (Standard) | ≥98% | Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile. | ||||||||||||||||||||
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Enpp-1-IN-10 | 98.64% | Enpp-1-IN-10 (compound 1) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 3.866 μM. Enpp-1-IN-10 can be used for researching anticancer. | ||||||||||||||||||||
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Nipamovir | 98.60% | Nipamovir is an orally active anti-HIV prodrug. Nipamovir is cleaved in vivo by glutathione and other active thiols. Nipamovir inhibits the replication of HIV-1RF and HIV-192HT599 in cells, with EC50 values of 3.64 μM and 3.23 μM, respectively. Nipamovir can be used in studies related to HIV infection. | ||||||||||||||||||||
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PLK1-IN-11 | 99.52% | PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor, with IC50 of 1 μM. PLK1-IN-11 can be used in research on a variety of cancers, including pancreatic, ovarian, breast, and non-small cell lung carcinoma. | ||||||||||||||||||||
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Azathioprine sodium | Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis. | |||||||||||||||||||||
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6-Benzylaminopurine (Standard) | 99.44% | 6-Benzylaminopurine (Standard) is the analytical standard of 6-Benzylaminopurine. This product is intended for research and analytical applications. 6-Benzylaminopurine (Benzyladenine) is a cytokinin that causes plant growth and development by stimulating cell division and inhibiting respiratory kinases, thereby prolonging the preservation of green vegetables. | ||||||||||||||||||||
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Phenyl(9H-purin-6-yl)amine | 99.48% | Phenyl(9H-purin-6-yl)amine is an antibacterial compound with the activity of inhibiting bacterial growth. The application of phenyl(9H-purin-6-yl)amine can be used to develop new antibacterial compounds. Phenyl(9H-purin-6-yl)amine has shown potential inhibitory effects in medical research. | ||||||||||||||||||||
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References
- [1]. Patel, A.A., R.A. Swerlick, and C.O. McCall, Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol, 2006. 55(3): p. 369-89. [Content Brief]
- [3]. Dubinsky, M.C., Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol, 2004. 2(9): p. 731-43. [Content Brief]
