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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
lysine 9
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "lysine 9" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-16705
CAS No.: 1374601-40-7
Target:
Research Areas:
BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 reduces di- and trimethylation of lysine 9 on histone H3 (H3K9) with an EC50 of 5 μM, and has less or little effect toward H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 can activate the ataxia telangiectasia mutated (ATM) pathway and induce cell senescence .
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OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX .
Cat. No.: HY-44062
CAS No.: 1350752-07-6
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G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer .
Cat. No.: HY-176036
CAS No.: 3070323-06-4
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MS1262 is a blood-brain barrier-permeable, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), with an IC50 of 19 nM and a Kd of 74 nM against G9a, and an IC50 of 6 nM and a Kd of 19 nM against GLP. MS1262 reduces the dimethylation level of histone H3 lysine 9 and decreases the size of Aβ plaques. MS1262 restores hippocampal long-term potentiation (LTP) and miniature excitatory postsynaptic current (sEPSC) frequency, ameliorates spatial memory deficits, and reverses anxiety-like and depression-like behaviors in AD model mice. MS1262 reverses the expression/phosphorylation levels of early AD biomarkers, providing support for stage-specific diagnosis of AD. MS1262 reduces the risk of thrombus rupture. MS1262 can be used in research related to Alzheimer's disease, colorectal cancer, and triple-negative breast cancer .
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DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562 .
Cat. No.: HY-119730
CAS No.: 1428962-73-5
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Tripartin is an inhibitor of histone demethylase. Tripartin inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells .
Cat. No.: HY-10587A
CAS No.: 1808255-64-2
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BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells .
Cat. No.: HY-122746
CAS No.: 1364914-62-4
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E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase .
Cat. No.: HY-P10111
CAS No.: 951011-30-6
Synonyms: H3(1-15)K9me3
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Cat. No.: HY-P703635
Synonyms: EHMT1; H3-K9-HMTase 5; Prev. EHMT1-IT1; EUHMTASE1; Eu-HMTase1; FLJ12879; KMT1D; FLJ40292; GLP; GLP1; KIAA1876; Histone-lysine N-Methyltransferase, H3 lysine-9 Specific 5; Euchromatic Histone-lysine N-Methyltransferase 1; [Histone H3]-lysine(9) N-Methyltra
Species:
Human
Source:
E. coli
Cat. No.: HY-P703636
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EHMT1; H3-K9-HMTase 5; Prev. EHMT1-IT1; EUHMTASE1; Eu-HMTase1; FLJ12879; KMT1D; FLJ40292; GLP; GLP1; KIAA1876; Histone-lysine N-Methyltransferase, H3 lysine-9 Specific 5; Euchromatic Histone-lysine N-Methyltransferase 1; [Histone H3]-lysine(9) N-Methyltra
Species:
Human
Source:
E. coli
Cat. No.: HY-P701618
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM4A; [Histone H3]-Trimethyl-L-lysine(9) Demethylase 4A; Prev. JMJD2A; lysine (K)-Specific Demethylase 4A; Prev. JMJD2; lysine-Specific Demethylase 4A; JHDM3A; Jumonji Domain Containing 2A; KIAA0677; Tudor Domain Containing 14A; TDRD14A; Jumonji Domain C
Species:
Human
Source:
E. coli
Cat. No.: HY-P701619
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM4A; [Histone H3]-Trimethyl-L-lysine(9) Demethylase 4A; Prev. JMJD2A; lysine (K)-Specific Demethylase 4A; Prev. JMJD2; lysine-Specific Demethylase 4A; JHDM3A; Jumonji Domain Containing 2A; KIAA0677; Tudor Domain Containing 14A; TDRD14A; Jumonji Domain C
Species:
Human
Source:
E. coli
Cat. No.: HY-187169
Research Areas:
KAT2A degrader-2 is a selective molecular glue degrader targeting KAT2A, with a DC50 of 22 nM in Kelly cells. KAT2A degrader-2 acts as a molecular glue to recruit KAT2A to CRBN, forming a ternary complex that drives the polyubiquitination and proteasome-dependent degradation of KAT2A. KAT2A degrader-2 reduces the acetylation level of histone H3 lysine 9 via the ubiquitin-like and proteasome-dependent pathway. KAT2A degrader-2 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P703619
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KDM4C; Jumonji Domain-Containing Protein 2C; Prev. JMJD2C; lysine-Specific Demethylase 4C; GASC1; Tudor Domain Containing 14C; KIAA0780; JHDM3C; TDRD14C; [Histone H3]-Trimethyl-L-lysine(9) Demethylase; JmjC Domain-Containing Histone Demethylation Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P702951
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDM4C; Jumonji Domain-Containing Protein 2C; Prev. JMJD2C; lysine-Specific Demethylase 4C; GASC1; Tudor Domain Containing 14C; KIAA0780; JHDM3C; TDRD14C; [Histone H3]-Trimethyl-L-lysine(9) Demethylase; JmjC Domain-Containing Histone Demethylation Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-187168
CAS No.: 2407654-72-0
Research Areas:
KAT2A degrader-1 is a molecular glue degrader targeting KAT2A, with a DC50 of 89 nM in Kelly cells. KAT2A degrader-1 recruits KAT2A to cereblon (CRBN) in a degron-independent manner, forms a ternary complex with KAT2A and CRBN, and drives the polyubiquitination and proteasome-dependent degradation of KAT2A. KAT2A degrader-1 reduces the level of histone H3 lysine 9 acetylation (H3K9Ac). KAT2A degrader-1 induces antiproliferative effects in acute myeloid leukemia cells, while enhancing KAT2A-CRBN dimerization activity and eliminating the targeting effect on GSPT1. KAT2A degrader-1 can be used for research related to acute myeloid leukemia .
Cat. No.: HY-176036A
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Research Areas:
MS1262 TFA is a blood-brain barrier-permeable, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), with an IC50 of 19 nM and a Kd of 74 nM against G9a, and an IC50 of 6 nM and a Kd of 19 nM against GLP. MS1262 TFA reduces the dimethylation level of histone H3 lysine 9 and decreases the size of Aβ plaques. MS1262 TFA restores hippocampal long-term potentiation (LTP) and miniature excitatory postsynaptic current (sEPSC) frequency, ameliorates spatial memory deficits, and reverses anxiety-like and depression-like behaviors in AD model mice. MS1262 TFA reverses the expression/phosphorylation levels of early AD biomarkers, providing support for stage-specific diagnosis of AD. MS1262 TFA reduces the risk of thrombus rupture. MS1262 TFA can be used in research related to Alzheimer's disease, colorectal cancer, and triple-negative breast cancer .
Cat. No.: HY-P703355
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDM16; MDS1/EVI1-Like Gene 1; PR/SET Domain 16; PR Domain 16; PFM13; MGC166915; MEL1; [Histone H3]-lysine(9) N-Methyltransferase; Transcription Factor MEL1; PR-Domain Zinc Finger Protein 16; KIAA1675; PR Domain-Containing Protein 16; KMT8F; Alternative P
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
