494786-13-9
Chemical Structure
DCG066
- CAS No.: 494786-13-9
- Formula:C30H31F6N3O2
- Molecular Weight:579.58
IUPAC Name: 3-(4-((4-(hydroxybis(4-(trifluoromethyl)phenyl)methyl)piperidin-1-yl)methyl)phenyl)-1,1-dimethylurea
InChIKey: PMPKMTDYPOAEEH-UHFFFAOYSA-N
SMILES: O=C(N(C)C)NC1=CC=C(C=C1)CN2CCC(CC2)C(O)(C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F
Biological Activity: DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DCG066 | 99.78% | DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
