5 Results for "

membrane protein biogenesis

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "membrane protein biogenesis" in MCE Product Catalog:

Cat. No.: HY-P10466A
KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
loading...
    loading...
Cat. No.: HY-P3987A
Target:  

Sec61

Research Areas:  

Cancer

Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research .
loading...
    loading...
Cat. No.: HY-P77133
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PEX11A; MGC119947; Peroxisomal biogenesis Factor 11 Alpha; MGC138534; Peroxisomal biogenesis Factor 11A; HsPEX11p; PMP28; CDNA FLJ10553 Fis, Clone NT2RP2002325, Highly Similar To Peroxisomal membrane protein 11A; Peroxisomal membrane protein 11A; PEX11A P
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P87647
Synonyms: Peroxisomal membrane protein 11B, Peroxin-11B, Peroxisomal biogenesis factor 11B, protein PEX11 homolog beta, PEX11-beta, PEX11B

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, FC, IF-Tissue

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P10466
CAS No.: 2377734-91-1
KZR-8445, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
loading...
    loading...