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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
morpholine
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "morpholine" in MCE Product Catalog:
Research Areas:
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma .
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Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma .
Cat. No.: HY-W007359
CAS No.: 123-90-0
Cat. No.: HY-76877
CAS No.: 132833-51-3
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4-(4-Bromobenzyl)morpholine is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-W015887R
CAS No.: 4394-85-8
Synonyms: N-Formylmorpholine (Standard)
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Morpholine-4-carbaldehyde (Standard) is the analytical standard of Morpholine-4-carbaldehyde. This product is intended for research and analytical applications.
Cat. No.: HY-154839
CAS No.: 2299227-75-9
c-Myc inhibitor 10 (compound 17), a c-Myc inhibitor, exhibits increased cellular potency, consistent with an increase in permeability with methylation of the morpholine nitrogen .
Cat. No.: HY-17653
CAS No.: 2243974-80-1
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Morpholino A phosphoramidite is a specialized chemical building block used to synthesize Phosphorodiamidate Morpholino Oligomers (PMOs). Morpholino A phosphoramidite contains the adenine (A) nucleobase attached to a morpholine ring, fitted with a phosphoramidite group. PMOs are synthetic gene knockdown tools heavily used in developmental biology and targeted therapeutics to inhibit gene expression or alter RNA splicing .
Cat. No.: HY-172333
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HCy-Lyso is a lysosome-targeting turn-on fluorescent probe based on hydrocyanine. HCy-Lyso integrates a hydrocyanine moiety for selective recognition of hydroxyl radicals (•OH) and a morpholine group for lysosome targeting. Upon reacting with •OH, HCy-Lyso undergoes an extension of its π-conjugation system, producing a strong fluorescence signal at 598 nm when excited at 510 nm .
Cat. No.: HY-176563
CAS No.: 2227349-05-3
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Di(4-morpholine-amide)-4-DTM-phenoxy(3,5-F)-PEG4-CH2COOH (compound BL) is a cleavable PEG-based ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-W766136
Synonyms: 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenyl-4-[(2-N-methoxycarbonyl)acetamidrazono]morpholine-13C2,d2
Cat. No.: HY-190681
Synonyms: α-Mangostin-C2-morpholine
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alpha-Mangostin-C2-morpholine (α-Mangostin-C2-morpholine) is a selective AChE inhibitor with an IC50 of 0.11 μM. alpha-Mangostin-C2-morpholine binds Aβ and inhibits self-induced aggregation and AChE-induced aggregation. alpha-Mangostin-C2-morpholine exhibits hydroxyl radical scavenging activity with an IC50 of 0.19 μM, and reduces ROS levels in C. elegans in vivo. alpha-Mangostin-C2-morpholine can be used for research on Alzheimer's disease .
Cat. No.: HY-W723905
CAS No.: 1219804-24-6
Cat. No.: HY-161836
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α2AR agonist 1 (compound S6a), a new morpholine-containing pyrimidinone, acts as an agonist of α2-adrenoceptor. α2AR agonist 1 induces a concentration-dependent relaxation on aortic ring pre-contracted with Phenylephrine (HY-B0769; pEC50=6.81). α2AR agonist 1 increases NOx and NO levels in HUVECs .
Cat. No.: HY-190480
CAS No.: 241139-69-5
PFM067-N-morpholine is an OSBP inhibitor that binds to the ORD domain of the host lipid transfer protein, which is involved in HSV-2 replication. PFM067-N-morpholine has a Kd of 4.93 μM for human OSBP. PFM067-N-morpholine inhibits HSV-2 replication with a selectivity index, with an EC50 of 8 nM in Hela cells. PFM067-N-morpholine can be used for research on HSV-2 infection .
Cat. No.: HY-W398889
CAS No.: 1094649-71-4
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3-Methyl-2-(p-tolyl) morpholine is a monoamine neurotransmitter modulator that regulates the neurotransmitter levels of dopamine, 5-hydroxytryptamine, and norepinephrine. 3-Methyl-2-(p-tolyl) morpholine can be used in research related to diseases such as addiction and depression .
Cat. No.: HY-W175598
CAS No.: 5625-90-1
Synonyms: N,N'-Methylene-bis-morpholine
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Bis(4-morpholinyl)methane (N,N'-Methylene-bis-morpholine) is a broad-spectrum, slow-release formaldehyde-based fungicide. Bis(4-morpholinyl)methane inhibits the growth and reproduction of microorganisms, and prevents spoilage and odor generation in humid environments. Bis(4-morpholinyl)methane serves as a preservative for natural rubber latex .
Cat. No.: HY-134096
CAS No.: 78323-98-5
Synonyms: DNS-M
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Dansyl-morpholine (DNS-M) is a Fluorescent probe for lipid droplet imaging, cancer cell discrimination, and real-time tracking of lipid droplet dynamics. As a solvatochromic probe with a donor-π-acceptor structure, it relies on hydrophobic interaction for its mechanism of action: its good lipophilicity, confirmed by an oil-water partition coefficient LogP = 2.35, allows it to rapidly penetrate cell membranes, and it specifically localizes to the hydrophobic core of lipid droplets; its fluorescence is strongly enhanced in the nonpolar environment of lipid droplets, while it emits very weak fluorescence in polar environments like PBS buffer, and it exhibits a bathochromic shift in emission wavelength with increasing solvent polarity. It has negligible cytotoxicity, with cell viability remaining over 95% after 24-hour incubation with 100 μM of the probe, and it possesses excellent photostability, retaining over 97% of initial fluorescence intensity after 60 continuous laser scans. For cell imaging applications, its excitation/emission wavelengths for lipid droplet labeling are Ex/Em = 405/480−540 nm, and in a simulative lipid environment O/W emulsion, it has an excitation wavelength of ~346 nm and emission wavelength of ~500 nm, giving a Stokes shift of 154 nm[1].
Cat. No.: HY-104052
CAS No.: 1582729-24-5
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MK-8718 is a potent and orally active HIV protease inhibitor containing a morpholine aspartate binding group. MK-8718 can be used for the research of infection .
Cat. No.: HY-D3112
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P2-Aggregate is a polarity-sensitive fluorescent probe for protein aggregation, which is based on the Nile Red scaffold and modified with a morpholine ring to enhance water solubility. P2-Aggregate improves anti-precipitation ability in aqueous phase via morpholine ring modification, and enables site-specific labeling of target proteins by combining with HaloTag technology. Utilizing the property that its emission wavelength blue-shifts with decreasing local polarity (excited at 543 nm), P2-Aggregate quantitatively detects changes in local polarity during protein aggregation and polarity heterogeneity inside aggregates in living cells. P2-Aggregate can be used in the research of diseases associated with the aggregation of Htt-110Q and SOD1 proteins, such as Huntington's disease and amyotrophic lateral sclerosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
