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myosin B

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標的別:	Myosin (4) Drug Derivative (1) ROCK (1)
研究分野別:	Cardiovascular Disease (2) Neurological Disease (1)

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Targets Recommended: Myosin

製品番号	製品名	Target	研究分野	構造式

HY-161608

Myosin modulator 1	Myosin	Cardiovascular Disease
Myosin modulator 1 (Compound B141) is a modulator for *myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 0.42, 0.13 and 3.09 μM, respectively. Myosin* modulator 1 regulates systolic cardiac performance in Sprague Dawley rats .

HY-161609

Myosin modulator 2	Myosin	Cardiovascular Disease
Myosin modulator 2 (Compound B172) is a modulator for *myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 2.013, 2.94 and 20.93 μM, respectively. Myosin* modulator 2 regulates systolic cardiac performance in Sprague Dawley rats .

HY-N15301

Nocarnickelamide B	ROCK Myosin	Others
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC₅₀s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch .

HY-134248

Tubercidin 5'-triphosphate 7-Deazaadenosine 5'-triphosphate	Drug Derivative Myosin	Neurological Disease
Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils .

製品番号	製品名	Category	Target	構造式

HY-N15301

Nocarnickelamide B	Microorganisms Ketones, Aldehydes, Acids Source Classification	ROCK Myosin
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC₅₀s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch .

Species:	Human (3)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

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HY-P704107

	MYL12B Protein, Human (His) MRLC2; MYLC2B; MLC-2A (MLC-2); myosin regulatory light chain 2-B, smooth muscle isoform; myosin regulatory light chain 20 kDa (MLC20); myosin regulatory light chain MRLC2; SHUJUN-1	Human	E. coli
	MYL12B Protein, Human (His) is the recombinant human-derived MYL12B protein, expressed by E. coli, with C-6*His tag.

HY-P704105

	MYL12A Protein, Human (His) myosin regulatory light chain 12A; MYL12A; MLCB; MRLC3; RLC; Epididymis secretory protein Li 24 (HEL-S-24); MLC-2B; myosin RLC; myosin regulatory light chain 2, nonsarcomeric; myosin regulatory light chain MRLC3	Human	E. coli
	MYL12A Protein, Human (His) is the recombinant human-derived MYL12A protein, expressed by E. coli, with C-6*His tag.

HY-P705598

	MYO3B Protein, Human (Active, sf9, GST) myosin-IIIb; EC:2.7.11.1; MYO3B	Human	Sf9 insect cells

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Host:	Mouse (1) Rabbit (5)
Reactivity:	Human (4) Rat (1) Mouse (5)
Application:	IHC-P (2) IP (2) WB (6)
Isotype:	IgG (5) IgG1 (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

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HY-P83369

	MYH10 Antibody (YA3114) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P83369A

	MYH10 Antibody (YA3114)(PBS only) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P83112

	MYH7B Antibody (YA2857) Myh7b; myosin-7B	WB, IHC-P	Human, Mouse, Rat
	MYH7B Antibody (YA2857) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH7B.

HY-P85290

	MYL3 Antibody (YA4982) MYL3; myosin light chain 3; Cardiac myosin light chain 1; CMLC1; myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain	WB, IHC-P	Human
	MYL3 Antibody (YA4982) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MYL3.

HY-P86696

	Myosin VIIa Antibody (YA6388) Deafness autosomal dominant 11; Deafness autosomal recessive 2; DFNA11; DFNB 2; DFNB2; Myo7a; myosin 7a; myosin VIIa; MYU7A; NSRD 2; NSRD2; Ush 1B; Ush1b; Usher syndrome 1B.	WB	Mouse
	Myosin VIIa Antibody (YA6388) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin VIIa.

HY-P86696A

	Myosin VIIa Antibody (YA6388)(PBS only) Deafness autosomal dominant 11; Deafness autosomal recessive 2; DFNA11; DFNB 2; DFNB2; Myo7a; myosin 7a; myosin VIIa; MYU7A; NSRD 2; NSRD2; Ush 1B; Ush1b; Usher syndrome 1B.	WB	Mouse
	Myosin VIIa Antibody (YA6388) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin VIIa.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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