109376-83-2
Chemical Structure
ML-7
- CAS No.: 109376-83-2
- Formula:C15H17IN2O2S
- Molecular Weight:416.28
IUPAC Name: 1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane
InChIKey: GEHJIACZUFWBTK-UHFFFAOYSA-N
SMILES: O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)I)=O
Biological Activity: ML-7 is a selective and highly specific myosin light chain kinase (MLCK) inhibitor that acts as a trabecular meshwork (TM) relaxant. ML-7 enhances Quinocetone (HY-123581)-induced phosphorylation of ERK, p38 MAPK and JNK, attenuates Akt activation, and promotes apoptosis of hepatocellular carcinoma cells. ML-7 reduces Th2 cytokine secretion by inhibiting MLCK, while alleviating smooth muscle hyperplasia and collagen deposition. As a non-antibiotic adjuvant, ML-7 restores the sensitivity of drug-resistant bacteria to Tigecycline (HY-B0117). ML-7 can be used in research related to glaucoma, hepatocellular carcinoma, asthma, and Klebsiella pneumoniae infection[1][2][3][4].
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ML-7 | ML-7 is a selective and highly specific myosin light chain kinase (MLCK) inhibitor that acts as a trabecular meshwork (TM) relaxant. ML-7 enhances Quinocetone (HY-123581)-induced phosphorylation of ERK, p38 MAPK and JNK, attenuates Akt activation, and promotes apoptosis of hepatocellular carcinoma cells. ML-7 reduces Th2 cytokine secretion by inhibiting MLCK, while alleviating smooth muscle hyperplasia and collagen deposition. As a non-antibiotic adjuvant, ML-7 restores the sensitivity of drug-resistant bacteria to Tigecycline (HY-B0117). ML-7 can be used in research related to glaucoma, hepatocellular carcinoma, asthma, and Klebsiella pneumoniae infection. | |||||||||||||||||||||
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References
- [1]. Zhou Y, et al. ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line. Toxicology mechanisms and methods. 2016;26(1):11-21. [Content Brief]
- [2]. Odani K, et al. ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner. Histochemistry and cell biology. 2003 May;119(5):363-70. [Content Brief]
- [3]. Rosenthal R, et al. Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork. Experimental eye research. 2005 Jun;80(6):837-45. [Content Brief]
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[4]. Sun L, et al. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Front Cell Infect Microbiol. 2022 Jan 5;11:809542.
[Content Brief]
