2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ML-7

ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury.

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CAS No. : 109376-83-2

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Top Publications Citing Use of Products

    ML-7 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27;24(7):6263.  [Abstract]

    ML-7 hydrochloride (ML-7; 10 μM; 2 h; pretreatment) significantly reduces the protein level of phosphorylated MLC2 and the phosphorylation ratio of MLC2 in BMECs.

    ML-7 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2021 Apr 14;69(14):4101-4110.  [Abstract]

    Relative protein expression of ZO-1 pretreated with 10 μmol/L ML7 for 1 h. ML7 directly inhibits the expression of ZO-1.

    ML-7 purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2020 Oct 10;332:146-154.  [Abstract]

    Cells are incubated with 10 μM ML-7 for 1 h, followed by incubation with 1.0 μM As2O3 for 24 h and assessment of occludin protein expression with Western blotting.

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    Description

    ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury[1].

    Cellular Effect
    Cell Line Type Value Description References
    Hippocampal neurone EC50
    74 nM
    Compound: ML-7
    Induction of neurite growth in rat hippocampal neurons incubated for 48 hrs by high content analysis
    Induction of neurite growth in rat hippocampal neurons incubated for 48 hrs by high content analysis
    		[PMID: 31518122]
    Molecular Weight

    416.28

    Formula

    C15H17IN2O2S
    CAS No.
    SMILES

    O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)I)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    ML-7 Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ML-7109376-83-2ML7ML 7Endogenous MetaboliteInhibitorinhibitorinhibit

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