16 Results for "

nanobodies

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "nanobodies" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99227
CAS No.: 915810-67-2
Synonyms: ALX-0681; ALX-0081
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .
loading...
    loading...
Cat. No.: HY-P99796
CAS No.: 1167985-17-2
Synonyms: ATN-103; PF-5230896

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis .
loading...
    loading...
Cat. No.: HY-W087027
CAS No.: 1295584-83-6
Maleimide-NOTA is a chelate. Maleimide-NOTA can be site-specifically coupled to the hPD-L1 nanobody bearing the Cys-tag. Maleimide-NOTA can specifically conjugate to A20FMDV2 (HY-P1654). The [ 68Ga]Ac-CG6 formed by the conjugation of 68Ga radiolabeled Maleimide-NOTA with A20FMDV2 can be used for PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma .
loading...
    loading...
Cat. No.: HY-112624A
CAS No.: 9004-54-0
Synonyms: Dextran 1; Dextran D1; Dextran T1(MW 800-1200)
Dextran T1 (Dextran 1; Dextran D1) (with a molecular weight of 1,000) is a dehydrated glucose polymer with an average molecular weight of 1,000. Dextran T1 (MW 1,000) has excellent biodegradability and biocompatibility, and can be used as a nanobody carrier scaffold and a freeze-drying protectant. Dextran T1 (MW 1,000) promotes the retention of circulating tumor cells in the capillary bed .
loading...
    loading...
Cat. No.: HY-P99397
CAS No.: 1414386-05-2
Synonyms: ALX 0761; M 1095

Target:  

Interleukin Related MMP

Research Areas:  

Inflammation/Immunology

Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serum albumin VHH antibodies. Sonelokimab can prolong the plasma half-life by binding to human serum albumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis .
loading...
    loading...
Cat. No.: HY-P99647
CAS No.: 1257358-38-5
Synonyms: ALX-0171; VR-465

Target:  

RSV

Research Areas:  

Infection

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung .
loading...
    loading...
Cat. No.: HY-P990748
CAS No.: 2770858-49-4
Synonyms: SAR443765

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Lunsekimig (SAR443765) is a nanobody composed of 5 VH domains that targets both TSLP and IL-13. Lunsekimig blocks the functional effects of TSLP and IL-13, inhibits related inflammatory signals, and improves lung function associated with type 2 inflammation. Lunsekimig can be used in research on asthma and type 2 inflammation .
loading...
    loading...
Cat. No.: HY-P990358

Research Areas:  

Inflammation/Immunology

Anti-CD7 Antibody is a VHH nanobody targeting CD7, and it is mainly used as a reference antibody.
loading...
    loading...
Cat. No.: HY-P990907
CAS No.: 2834733-45-6
Synonyms: F-027300252; SAR-442970

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Brivekimig (F-027300252; SAR-442970) is a bispecific nanobody targeting TNF/OX40L. Brivekimig is applicable to research related to hidradenitis suppurativa.
loading...
    loading...
Cat. No.: HY-P991725
CAS No.: 3036636-75-3
Synonyms: ZL-1102

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Velvakiment is a humanized VHH nanobody that targets IL-17A. Velvakiment can be used for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis research .
loading...
    loading...
Cat. No.: HY-P991866

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

BI 1034020 is a humanized nanobody, targeting two different epitopes of ( Aβ40 and Aβ42) with high affinity. BI 1034020 reduces the level of free Ab peptide in plasma and thus prevent the formation of new Aβ plaques and clear existing plaques. BI 1034020 can be used for Alzheimer’s disease research .
loading...
    loading...
Cat. No.: HY-P992457

Research Areas:  

Cancer

SAR444200 is a nanobody targeting GPC3 (glypican-3) and TCRαβ (T-cell receptor αβ). The KD of SAR444200 for human GPC3 is 0.023 nM, and its KD for human TCRαβ is 5.2 nM. SAR444200 mediates T cell-dependent cytotoxicity, and exhibits high selectivity and killing activity against GPC3-positive tumor cells. SAR444200 binds to GPC3 in a dual-epitope manner, and binds to TCRαβ via its N-terminal nanobody, forming an artificial immunological synapse between T cells and tumor cells. SAR444200 can be used in studies of GPC3+ solid tumors, including liver cancer, lung squamous cell carcinoma and melanoma .
loading...
    loading...
Cat. No.: HY-P992473

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

TAS266 is a tetrameric nanobody agonist targeting DR5. TAS266 selectively induces cancer cell death. TAS266 triggers sustained tumor regression in xenograft models and also elicits immunogenic responses including antibody binding. TAS266 exhibits superior anti-tumor efficacy compared with traditional DR5-targeting strategies. TAS266 can be used in research related to pancreatic cancer and advanced solid tumors .
loading...
    loading...
Cat. No.: HY-186245
CAS No.: 3079850-64-6
Research Areas:  

Cancer

RESCA-Maleimide is a bifunctional chelator. RESCA-Maleimide can be conjugated with small proteins targeting PD-L1 to prepare radionuclide-labeled PD-L1 imaging probes. RESCA-Maleimide is applicable to the research of PD-L1-positive tumors .
loading...
    loading...
Cat. No.: HY-178271
CAS No.: 147597-66-8
Target:  

Drug Intermediate

Research Areas:  

Cancer

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors .
loading...
    loading...
Cat. No.: HY-P992323

Target:  

VEGFR Tie ERK

Research Areas:  

Cardiovascular Disease Cancer

BI-836880 is a humanized bispecific nanobody and a selective inhibitor of VEGF and ANG2, with a Kd of 16 pM for hANG2, an EC50 of 1.4 nM for VEGF165, and an EC50 of 2.3 nM for VEGF121. BI-836880 blocks ERK phosphorylation downstream of VEGF-A as well as TIE2 phosphorylation downstream of ANG2. BI-836880 does not inhibit ANG1-mediated TIE2 phosphorylation. BI-836880 exerts anti-angiogenic effects, reduces the number of immature endothelial vessels in tumor tissues, and inhibits tumor growth in preclinical models. BI-836880 can be used in the research of pancreatic cancer, non-small cell lung cancer, renal cell carcinoma, ovarian cancer, colon cancer, and Lewis lung cancer .
loading...
    loading...
  • 1