8 Results for "

nicastrin

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "nicastrin" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N2319
CAS No.: 24730-10-7
Synonyms: DHEC mesylate
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively .
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Cat. No.: HY-P992275

Target:  

γ-secretase

Research Areas:  

Neurological Disease Cancer

Anti-Nicastrin Antibody (A5226A) is a monoclonal antibody against Nicastrin and an inhibitor of γ-secretase. Anti-Nicastrin Antibody (A5226A) recognizes the fully glycosylated mature presenilin enhancer in the active γ-secretase complex and inhibits its activity via competition for substrate binding. Anti-Nicastrin Antibody (A5226A) abrogates the growth of cancer cells dependent on γ-secretase activity. Anti-Nicastrin Antibody (A5226A) serves as an imaging tool to visualize the endocytic trafficking of active γ-secretase, and also acts as a detection reagent to evaluate the endocytic efficiency of γ-secretase. Anti-Nicastrin Antibody (A5226A) can be used in studies related to non-small cell lung cancer, T-cell acute lymphoblastic leukemia and Alzheimer's disease .
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Cat. No.: HY-N2319R
CAS No.: 24730-10-7
Synonyms: DHEC mesylate (Standard)
Research Areas:  

Neurological Disease

Dihydroergocristine (mesylate) (Standard) is the analytical standard of Dihydroergocristine (mesylate). This product is intended for research and analytical applications. Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively .
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Cat. No.: HY-P74696
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NCSTN; APH2; nicastrin; Anterior Pharynx-Defective 2; KIAA0253; ATAG1874
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P74698
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NCSTN; APH2; nicastrin; Anterior Pharynx-Defective 2; KIAA0253; ATAG1874
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P74697
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NCSTN; APH2; nicastrin; Anterior Pharynx-Defective 2; KIAA0253; ATAG1874
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P81652
Synonyms: APH2; Ncstn; NCT; nicastrin

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P81652A
Synonyms: APH2; Ncstn; NCT; nicastrin

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

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