2 Results for "

peripheral regulatory T cell proliferation

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "peripheral regulatory T cell proliferation" in MCE Product Catalog:

Efizonerimod alfa
Efizonerimod alfa
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Cat. No.: HY-P99911
CAS No.: 1635395-27-5
Synonyms: MEDI-6383

Target:  

Orexin Receptor (OX Receptor)

Research Areas:  

Inflammation/Immunology Cancer

Efizonerimod alfa (MEDI-6383) is a recombinant human OX40L IgG4P Fc fusion protein that assembles into a hexameric structure and exerts potent agonist activity upon binding to OX40. The activity of Efizonerimod alfa is enhanced by Fcγ receptor-mediated aggregation. Efizonerimod alfa binds to OX40 on the surface of activated T cells, induces NF-κB promoter activity in OX40-expressing T cells, and triggers the production of Th1-type cytokines, T cell proliferation, and resistance to regulatory T cell (Treg)-mediated suppression. Efizonerimod alfa enhances the cytolytic activity of tumor-reactive T cells and slows tumor growth in immunodeficient mice. Efizonerimod alfa induces the proliferation of CD4, CD8, and B cells in the peripheral blood of healthy non-human primates. Efizonerimod alfa can be used in the research of advanced solid malignancies and melanoma .
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GIGA-564
GIGA-564
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Cat. No.: HY-P991958

Target:  

CTLA-4

Research Areas:  

Cancer

GIGA-564 is a fully human anti-CTLA4 IgG1 monoclonal antibody with a Kd of 9.8 nM. GIGA-564 binds to a unique epitope of CTLA-4, mediates FcR-dependent signaling pathways, depletes CTLA-4-highly-expressing regulatory T cells within tumors, and inhibits the proliferation of peripheral regulatory T cells. GIGA-564 exhibits anti-tumor activity in mouse models. GIGA-564 can be used for tumor research .
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