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Results for "

polymerase acidic

" in MedChemExpress (MCE) Product Catalog:

11

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6733
    Aphidicolin
    10+ Cited Publications

    		 DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus Infection Inflammation/Immunology
    Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
    Aphidicolin
  • HY-134539
    IMT1
    5+ Cited Publications

    		 Oxidative Phosphorylation Mitochondrial Metabolism DNA/RNA Synthesis Metabolic Disease Cancer
    IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases .
    IMT1
  • HY-E70529
    Ribonucleoside vanadyl complexes

    		DNA/RNA Synthesis Bacterial Infection
    Ribonucleoside vanadyl complexes are a class of potent RNase and Taq polymerase inhibitors. Ribonucleoside vanadyl complexes protect RNA during RNA isolation by inhibiting ribonucleases, and also reduce the viability of bacteria and eukaryotic cells by interfering with ribosomal subunit assembly. Ribonucleoside vanadyl complexes block PCR and reverse transcription reactions templated by viral nucleic acids and enhance the effects of antibiotics against Staphylococcus aureus, but do not directly inhibit protein synthesis. Ribonucleoside vanadyl complexes can be effectively removed by phenol-chloroform extraction, thus enabling subsequent PCR analysis. Ribonucleoside vanadyl complexes can be applied in research related to chronic hepatitis C (HCV) and Staphylococcus aureus infection .
    Ribonucleoside vanadyl complexes
  • HY-135751
    Holomycin

    		Antibiotic Bacterial DNA/RNA Synthesis Infection Cancer
    Holomycin is an antibiotic with dithiolopyrrolone structure. Holomycin can inhibit bacterial RNA synthesis. Holomycin has antitumor activity. Holomycin can be used for the research of bacterial infection .
    Holomycin
  • HY-177555
    AV5116

    		Influenza Virus Endonuclease Infection
    AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
    AV5116
  • HY-W048492
    7-Iodo-7-deaza-2'-deoxyguanosine

    7-Deaza-7-Iodo-2'-deoxyguanosine

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a modified deoxyguanosine nucleoside. 7-Iodo-7-deaza-2'-deoxyguanosine is used in DNA synthesis and sequencing reactions .
    7-Iodo-7-deaza-2'-deoxyguanosine
  • HY-152078
    Influenza virus-IN-6

    		Influenza Virus Infection
    Influenza virus-IN-6 (Compound 35) is a potent influenza N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease inhibitor with an IC50 of 0.20 μM .
    Influenza virus-IN-6
  • HY-170440
    ATV2301

    		Influenza Virus Infection Inflammation/Immunology
    ATV2301 is an orally active anti-influenza agent (EC50, H1N1 = 1.88 nM, H3N2 = 4.77 nM). ATV2301’s anti-influenza activity is due to its effects on polymerase acid protein (PA), nuclear protein (NP), and RNA-dependent RNA polymerase (RdRp) .
    ATV2301
  • HY-N6733R
    Aphidicolin (Standard)

    		Reference Standards DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus Infection Inflammation/Immunology
    Aphidicolin (Standard) is the analytical standard of Aphidicolin. This product is intended for research and analytical applications. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
    Aphidicolin (Standard)
  • HY-168510
    ATV03

    		Influenza Virus Infection
    ATV03 is an anti-influenza virus agent with excellent anti-influenza A and B virus activity. ATV03 inhibits anti-influenza A (H3N2) and anti-influenza B with EC50 values of 0.78 nM and 2.02 nM, respectively. ATV03 exerts anti-influenza activity by inhibiting polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as disrupting nuclear protein .
    ATV03
  • HY-163147
    PAN endonuclease-IN-1

    		Influenza Virus DNA/RNA Synthesis Infection
    PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target .
    PAN endonuclease-IN-1

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