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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
polymerase acidic
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "polymerase acidic" in MCE Product Catalog:
17
17 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
11
11 Cited Publications
Research Areas:
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases .
Cat. No.: HY-E70529
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Ribonucleoside vanadyl complexes are a class of potent RNase and Taq polymerase inhibitors. Ribonucleoside vanadyl complexes protect RNA during RNA isolation by inhibiting ribonucleases, and also reduce the viability of bacteria and eukaryotic cells by interfering with ribosomal subunit assembly. Ribonucleoside vanadyl complexes block PCR and reverse transcription reactions templated by viral nucleic acids and enhance the effects of antibiotics against Staphylococcus aureus, but do not directly inhibit protein synthesis. Ribonucleoside vanadyl complexes can be effectively removed by phenol-chloroform extraction, thus enabling subsequent PCR analysis. Ribonucleoside vanadyl complexes can be applied in research related to chronic hepatitis C (HCV) and Staphylococcus aureus infection .
Target:
Holomycin is an antibiotic with dithiolopyrrolone structure. Holomycin can inhibit bacterial RNA synthesis. Holomycin has antitumor activity. Holomycin can be used for the research of bacterial infection .
Cat. No.: HY-177555
CAS No.: 2417851-90-0
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AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
Cat. No.: HY-W048492
CAS No.: 172163-62-1
Synonyms: 7-Deaza-7-Iodo-2'-deoxyguanosine
Cat. No.: HY-152078
CAS No.: 2919303-26-5
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Influenza virus-IN-6 (Compound 35) is a potent influenza N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease inhibitor with an IC50 of 0.20 μM .
Cat. No.: HY-170440
CAS No.: 3049172-60-0
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ATV2301 is an orally active anti-influenza agent (EC50, H1N1 = 1.88 nM, H3N2 = 4.77 nM). ATV2301’s anti-influenza activity is due to its effects on polymerase acid protein (PA), nuclear protein (NP), and RNA-dependent RNA polymerase (RdRp) .
Cat. No.: HY-N6733R
CAS No.: 38966-21-1
Category:
Cat. No.: HY-168510
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ATV03 is an anti-influenza virus agent with excellent anti-influenza A and B virus activity. ATV03 inhibits anti-influenza A (H3N2) and anti-influenza B with EC50 values of 0.78 nM and 2.02 nM, respectively. ATV03 exerts anti-influenza activity by inhibiting polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as disrupting nuclear protein .
Cat. No.: HY-163147
CAS No.: 2378640-67-4
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PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target .
Cat. No.: HY-L044
590 compounds
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.
MCE offers a unique collection of 590 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).
Cat. No.: HY-N21925
CAS No.: 18449-25-7
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Target:
Cat. No.: HY-W1061847
Research Areas:
5-VIC Phosphoramidite is a Fluorescent dye and a component of TaqMan probes for nucleic acid detection. 5-VIC Phosphoramidite serves as a 5' reporter dye, which is conjugated to probes targeting the conserved region of the S protein of porcine epidemic diarrhea virus genotype GII, and is used with Eclipse® Dark Quencher for duplex real-time quantitative PCR. 5-VIC Phosphoramidite-labeled probes targeting the Rv0222 gene in the RD4 region specific to Mycobacterium tuberculosis are applied in triplex droplet digital PCR to differentiate mycobacterial strains. During PCR amplification, the 5'→3' exonuclease activity of Taq polymerase mediates the separation of 5-VIC Phosphoramidite from the quencher, thereby generating a detectable fluorescent signal .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
