6 Results for "

progranulin protein

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "progranulin protein" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99688
CAS No.: 2376132-27-1
Synonyms: AL001

Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease Cancer

Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .
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1
1 Cited Publications
Cat. No.: HY-P74618A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P991664
AG01 is a monoclonal antibody against progranulin (GP88). AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers .
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Cat. No.: HY-163543
Research Areas:  

Neurological Disease

Progranulin modulator-2 (compound 18A) is a bromodomain and extra-terminal domain (BET) inhibitor. Progranulin modulator-2 enhances PGRN expression by targeting members of the BET protein family. Progranulin modulator-2 can be used to study the role of BET protein in neurodevelopment, neuroplasticity and neurodegeneration .
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Cat. No.: HY-P78302
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P74618
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:  
Human
Source:  
HEK293
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